Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | LDLR | P01130 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13679559 | 0.83 | MEN1 (0.78) | ADORA2AMEN1KMT2AHTTMAPT | |
| SCHEMBL13679715 | 0.81 | MAPT (0.69) | ADORA2AMEN1KMT2AMAPTRAB9A | |
| SCHEMBL13679540 | 0.80 | RAF1 (0.59) | ADORA2AMEN1KMT2AHTTMAPT | |
| SCHEMBL14615300 | 0.80 | MAPT (0.71) | ADORA2AMEN1KMT2AHTTMAPT | |
| SCHEMBL13679583 | 0.80 | MAPT (0.80) | ADORA2AMEN1KMT2AHTTMAPT | |
| SCHEMBL14615299 | 0.79 | MAPT (0.66) | MEN1KMT2AHTTMAPTKDM4E | |
| SCHEMBL13456646 | 0.79 | MAPT (0.58) | ADORA2AMEN1KMT2AHTTMAPT | |
| SCHEMBL14642443 | 0.79 | MEN1 (0.72) | ADORA2AMEN1KMT2AHTTMAPT | |
| SCHEMBL13679606 | 0.75 | MAPT (0.66) | MEN1KMT2AMAPTLDLRKDM4E | |
| SCHEMBL13679620 | 0.75 | LDLR (0.65) | MAPTLDLRKDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482928-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS,COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2009-09-23 | — | — | EP | disclosed |