Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CCR9 | P51686 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | EDNRA | P25101 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TERT | O14746 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13457662 | 0.86 | LMNA (0.46) | TDP1SMN1; SMN2ALDH1A1CYP3A4CCR9 | |
| SCHEMBL11405994 | 0.73 | CRHBP (0.53) | TDP1SMN1; SMN2ALDH1A1CYP3A4LMNA | |
| SCHEMBL9007875 | 0.71 | ALDH1A1 (0.52) | TDP1SMN1; SMN2ALDH1A1CYP3A4LMNA | |
| SCHEMBL2184586 | 0.71 | MEN1 (0.48) | TDP1ALDH1A1CYP3A4CCR9LMNA | |
| SCHEMBL30354985 | 0.71 | CA1 (0.57) | TDP1SMN1; SMN2ALDH1A1CYP3A4LMNA | |
| SCHEMBL29151297 | 0.71 | CA1 (0.57) | TDP1SMN1; SMN2ALDH1A1CYP3A4LMNA | |
| Sulfamethazine SCHEMBL28447030 | 0.70 | ALDH1A1 (0.86) | TDP1SMN1; SMN2ALDH1A1CYP3A4LMNA | |
| SCHEMBL2177837 | 0.70 | CYP2C19 (0.68) | TDP1SMN1; SMN2ALDH1A1CYP3A4LMNA | |
| SCHEMBL5317017 | 0.69 | HDAC3 (0.56) | TDP1SMN1; SMN2LMNACYP2C9DHFR | |
| SCHEMBL23461180 | 0.69 | PIK3CD (0.49) | TDP1SMN1; SMN2ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010026121-A1 | BICYCLIC KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-03-11 | — | — | WO | disclosed |