Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 6/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.51 |
| ▸ | RELA | Q04206 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29496947 | 0.98 | CYP19A1 (0.64) | CYP19A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL913393 | 0.98 | CYP19A1 (0.64) | CYP19A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL31400263 | 0.91 | NPC1 (0.56) | CYP19A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL21988541 | 0.91 | NPC1 (0.56) | CYP19A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL28428427 | 0.88 | ABL1 (0.57) | CYP19A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL12393770 | 0.86 | KDR (0.58) | CYP19A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5572769 | 0.85 | CYP1A2 (0.55) | CYP19A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7454751 | 0.84 | NPC1 (0.57) | NPC1RAB9AL3MBTL1HSP90AA1PKM | |
| SCHEMBL22142572 | 0.84 | TGFBR1 (0.59) | CYP19A1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL31260432 | 0.84 | NPC1 (0.57) | NPC1RAB9AL3MBTL1HSP90AA1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168576-A2 | New utilities of tricyclic compounds | Shionogi & Co., Ltd. (JP) | 2010-03-31 | — | — | EP | disclosed |
| US-20080318958-A1 | New utilities of tricyclic compounds | ISHIZUKA NATSUKI | 2008-12-25 | — | — | US | disclosed |
| US-20080318958-A1 | New utilities of tricyclic compounds | ISHIZUKA NATSUKI | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318958-A1 | New utilities of tricyclic compounds | APOB, PON1, APOL1 | CYP19A1 333/4885CYP1A2 153/4885CYP2D6 197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.