Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | TYR | P14679 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6691430 | 0.81 | TYR (0.47) | PYCR1PDPK1BCAT2TDP1MTNR1B | |
| SCHEMBL223670 | 0.79 | TYR (0.47) | PYCR1PDPK1BCAT2TDP1MTNR1B | |
| SCHEMBL30294101 | 0.78 | TYR (0.50) | PYCR1PDPK1LMNAALDH1A1TDP1 | |
| SCHEMBL13464690 | 0.78 | TYR (0.50) | PYCR1PDPK1LMNAALDH1A1TDP1 | |
| SCHEMBL9710376 | 0.78 | TYR (0.50) | PYCR1PDPK1LMNAALDH1A1TDP1 | |
| SCHEMBL13464625 | 0.78 | TYR (0.50) | PYCR1PDPK1LMNAALDH1A1TDP1 | |
| SCHEMBL5404668 | 0.77 | PYCR1 (0.47) | PYCR1PDPK1BCAT2MTNR1BAKR1B1 | |
| SCHEMBL13470664 | 0.74 | CYP1A2 (0.41) | LMNAALDH1A1TDP1CYP3A4TSHR | |
| SCHEMBL29240143 | 0.74 | ALDH1A1 (0.32) | LMNAALDH1A1TDP1CYP3A4TSHR | |
| SCHEMBL13470657 | 0.73 | PDE2A (0.40) | BCAT2LMNAALDH1A1TDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697212-B1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN INC (US) | 2015-09-09 | — | — | EP | disclosed |
| EP-2697212-B1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN INC (US) | 2015-09-09 | — | — | EP | disclosed |
| US-8653050-B2 | Phenyl bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators | ALLERGAN, INC. (US) | 2014-02-18 | — | — | US | disclosed |
| US-8653050-B2 | Phenyl bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators | ALLERGAN, INC. (US) | 2014-02-18 | — | — | US | disclosed |
| US-8541582-B2 | Phenyl bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators | ALLERGAN, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| US-8541582-B2 | Phenyl bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators | ALLERGAN, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| US-20120264716-A1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN, INC. | 2012-10-18 | — | — | US | disclosed |
| US-20120264716-A1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN, INC. | 2012-10-18 | — | — | US | disclosed |
| WO-2012142288-A1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN, INC. (US) | 2012-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264716-A1 | PHENYL BICYCLIC METHYL AMINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | S1PR1, S1PR3, S1PR2 | PYCR1 2513/4885PDPK1 198/4885BCAT2 3890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.