Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 3/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23219796 | 0.87 | TDP1 (0.41) | PLA2G1BATG4BPDE10AHRH3PDE7A | |
| SCHEMBL20940096 | 0.85 | PDE10A (0.39) | PLA2G1BATG4BPDE10APDE7AL3MBTL3 | |
| SCHEMBL20940095 | 0.81 | PDE10A (0.37) | PLA2G1BATG4BPDE10AHRH3PDE7A | |
| SCHEMBL23219795 | 0.81 | VNN1 (0.41) | PLA2G1BATG4BPDE10APDE7AL3MBTL3 | |
| SCHEMBL13466364 | 0.79 | PLA2G1B (0.45) | PLA2G1BATG4BPDE10AHRH3L3MBTL3 | |
| SCHEMBL13467096 | 0.77 | PDE10A (0.56) | PDE10AL3MBTL3L3MBTL1NAMPTTDP1 | |
| SCHEMBL3232177 | 0.74 | IRAK4 (0.42) | PDE10AL3MBTL3L3MBTL1TDP1VNN1 | |
| SCHEMBL20254512 | 0.74 | SMN1; SMN2 (0.41) | PDE10AL3MBTL3L3MBTL1TDP1VNN1 | |
| SCHEMBL23880060 | 0.73 | SCN9A (0.46) | PLA2G1BATG4BPDE10AL3MBTL3L3MBTL1 | |
| SCHEMBL21379476 | 0.72 | PLA2G1B (0.47) | PLA2G1BATG4BPDE7AL3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180009816-A1 | HETEROCYCLIC COMPOUNDS AS PI3K-y INHIBITORS | INCYTE CORPORATION | 2018-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180009816-A1 | HETEROCYCLIC COMPOUNDS AS PI3K-y INHIBITORS | PIK3R5, PIK3CA, PIK3CD | PLA2G1B 1139/4885ATG4B 4184/4885PDE10A 583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.