Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4022870 | 0.88 | ALDH1A1 (0.48) | ALDH1A1HTTSMN1; SMN2POLBLMNA | |
| SCHEMBL23144924 | 0.87 | ALDH1A1 (0.41) | DPP4DPP7ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16083080 | 0.83 | ALDH1A1 (0.47) | DPP4ALDH1A1HTTSMN1; SMN2POLB | |
| SCHEMBL10305031 | 0.80 | OPRM1 (0.50) | DPP4DPP7ALDH1A1LMNAGRIN2B | |
| SCHEMBL16215801 | 0.80 | DPP4 (0.41) | DPP4DPP7ALDH1A1LMNAGRIN2B | |
| SCHEMBL14305080 | 0.80 | DPP4 (0.45) | DPP4DPP7ALDH1A1LMNAGRIN2B | |
| SCHEMBL17057261 | 0.77 | ITGB3 (0.41) | DPP4DPP7ALDH1A1LMNAKDM4E | |
| SCHEMBL9946439 | 0.77 | OPRM1 (0.45) | DPP4DPP7ALDH1A1POLBLMNA | |
| SCHEMBL12763806 | 0.77 | POLB (0.46) | DPP4DPP7ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL5189159 | 0.77 | DPP4 (0.45) | DPP4DPP7HPGDNAMPTFAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250136598-A1 | SUBSTITUTED PYRAZOLO-PYRIDINE AMIDES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2025-05-01 | — | — | US | disclosed |
| US-12172997-B2 | Substituted pyrazolo-pyridine amides and their use as GluN2B receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2024-12-24 | — | — | US | disclosed |
| US-20230250096-A1 | SUBSTITUTED PHENYL-1H-PYRROLO[2,3-c] PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2023-08-10 | — | — | US | disclosed |
| US-20230250096-A1 | SUBSTITUTED PHENYL-1H-PYRROLO[2,3-c] PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2023-08-10 | — | — | US | disclosed |
| US-20230151006-A1 | SUBSTITUTED PYRAZOLO-PYRIDINE AMIDES AND THEIR USE AS GLUN2B RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2023-05-18 | — | — | US | disclosed |
| US-20230151006-A1 | SUBSTITUTED PYRAZOLO-PYRIDINE AMIDES AND THEIR USE AS GLUN2B RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2023-05-18 | — | — | US | disclosed |
| US-20230151006-A1 | SUBSTITUTED PYRAZOLO-PYRIDINE AMIDES AND THEIR USE AS GLUN2B RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2023-05-18 | — | — | US | disclosed |
| US-11618750-B2 | Substituted pyrazolo-pyridine amides and their use as GluN2B receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-04-04 | — | — | US | disclosed |
| WO-2022253167-A1 | SUBSTITUTED PHENYL-1H-PYRROLO [2, 3-c] PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2022-12-08 | — | — | WO | disclosed |
| EP-3983075-A1 | SUBSTITUTED PYRAZOLO-PYRIDINE AMIDES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | disclosed |
| WO-2013157562-A1 | NITROGENATED BICYCLIC AROMATIC HETEROCYCLIC COMPOUND | アステラス製薬株式会社 (JP) | 2013-10-24 | — | — | WO | disclosed |
| US-8063045-B2 | Fluoropyrrolidines having dipeptidyl peptidase enzyme inhibitory activity | SANOFI-AVENTIS (FR) | 2011-11-22 | — | — | US | disclosed |
| US-20100210838-A1 | FLUOROPYRROLIDINES HAVING DIPEPTIDYL PEPTIDASE ENZYME INHIBITORY ACTIVITY | SANOFI-AVENTIS (FR) | 2010-08-19 | — | — | US | disclosed |
| US-7655663-B2 | Fluoropyrrolidines having dipeptidyl peptidase enzyme inhibitory activity | SANOFI-AVENTIS (FR) | 2010-02-02 | — | — | US | disclosed |
| EP-1487807-B1 | Cyano-pyrrolidines as DPP-IV inhibitors | SANOFI AVENTIS (FR) | 2009-09-16 | — | — | EP | disclosed |
| US-20080161310-A1 | FLUOROPYRROLIDINES HAVING DIPEPTIDYL PEPTIDASE ENZYME INHIBITORY ACTIVITY | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | US | disclosed |
| US-7348327-B2 | Compounds | SANOFI-AVENTIS (FR) | 2008-03-25 | — | — | US | disclosed |
| US-20050130981-A1 | Compounds | SANOFI-AVENTIS (FR) | 2005-06-16 | — | — | US | disclosed |
| EP-1487807-A2 | NEW COMPOUNDS | Sanofi-Aventis (FR) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003074500-A2 | N-AMINOACETYL-PYRROLIDINE-2-CARBONITRILES AND THEIR USE AS DDP-IV INHIBITORS | SANOFI-AVENTIS (FR) | 2003-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161310-A1 | FLUOROPYRROLIDINES HAVING DIPEPTIDYL PEPTIDASE ENZYME INHIBITORY ACTIVITY | DPP4, DPP3, DPP7 | DPP4 1/4885DPP7 3/4885ALDH1A1 338/4885 |
| US-20050130981-A1 | Compounds | DPP4, DPP3, DPP7 | DPP4 1/4885DPP7 3/4885ALDH1A1 242/4885 |
| US-12172997-B2 | Substituted pyrazolo-pyridine amides and their use as GluN2B receptor modulators | GRIN2B, GRIN2A, GRIN3A | DPP4 2266/4885DPP7 2034/4885ALDH1A1 2437/4885 |
| US-20230151006-A1 | SUBSTITUTED PYRAZOLO-PYRIDINE AMIDES AND THEIR USE AS GLUN2B RECEPTOR | GRIN2B, GRIN2A, GRIN3A | DPP4 1826/4885DPP7 1486/4885ALDH1A1 2278/4885 |
| US-20250136598-A1 | SUBSTITUTED PYRAZOLO-PYRIDINE AMIDES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | GRIN2B, GRIN2A, GRIN3A | DPP4 2266/4885DPP7 2034/4885ALDH1A1 2437/4885 |
| US-20230250096-A1 | SUBSTITUTED PHENYL-1H-PYRROLO[2,3-c] PYRIDINE DERIVATIVES | MLLT1, BMI1, MEN1 | DPP4 3032/4885DPP7 2498/4885ALDH1A1 2922/4885 |
| US-20100210838-A1 | FLUOROPYRROLIDINES HAVING DIPEPTIDYL PEPTIDASE ENZYME INHIBITORY ACTIVITY | DPP4, DPP3, DPP7 | DPP4 1/4885DPP7 3/4885ALDH1A1 338/4885 |
| US-11618750-B2 | Substituted pyrazolo-pyridine amides and their use as GluN2B receptor modulators | GRIN2B, GRIN2A, GRIN3A | DPP4 2266/4885DPP7 2034/4885ALDH1A1 2437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.