Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.84 |
| ▸ | PLEC | Q15149 | 1/20 | 0.84 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.84 |
| ▸ | MAPT | P10636 | 4/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.73 |
| ▸ | CASP3 | P42574 | 1/20 | 0.73 |
| ▸ | HTT | P42858 | 1/20 | 0.73 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.73 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.68 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.65 |
| ▸ | RAB9A | P51151 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.65 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10026686 | 0.90 | POLB (0.86) | POLBPLECCTDSP1TDP1MAPT | |
| SCHEMBL8767795 | 0.89 | HDAC3 (0.72) | POLBPLECCTDSP1TDP1MAPT | |
| SCHEMBL17825555 | 0.89 | POLB (0.84) | POLBPLECCTDSP1TDP1MAPT | |
| SCHEMBL17825558 | 0.89 | POLB (0.84) | POLBPLECCTDSP1TDP1MAPT | |
| SCHEMBL12443154 | 0.87 | POLB (0.78) | POLBPLECCTDSP1TDP1MAPT | |
| SCHEMBL22925052 | 0.87 | POLB (0.82) | POLBPLECCTDSP1TDP1MAPT | |
| SCHEMBL711755 | 0.84 | RAB9A (0.81) | POLBTDP1MAPTCYP1A2CYP2C9 | |
| SCHEMBL2830919 | 0.84 | RAB9A (0.81) | POLBTDP1MAPTCYP1A2CYP2C9 | |
| SCHEMBL711754 | 0.84 | RAB9A (0.81) | POLBTDP1MAPTCYP1A2CYP2C9 | |
| SCHEMBL13475704 | 0.83 | ALDH1A1 (0.80) | POLBPLECCTDSP1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029773-A1 | Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift) | LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN (DE) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029773-A1 | Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift) | PRNP, MAPT, HTT | POLB 3948/4885PLEC 884/4885CTDSP1 3575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.