Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.48 |
| ▸ | ORAI2 | Q96SN7 | 2/20 | 0.48 |
| ▸ | ORAI3 | Q9BRQ5 | 2/20 | 0.48 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.39 |
| ▸ | GGT1 | P19440 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9621660 | 0.82 | ALDH1A1 (0.44) | ORAI1ORAI2ORAI3TRPV6ALDH1A1 | |
| SCHEMBL6911660 | 0.81 | ORAI1 (0.52) | ORAI1ORAI2ORAI3TRPV6ALDH1A1 | |
| SCHEMBL651370 | 0.80 | ORAI1 (0.42) | ORAI1ORAI2ORAI3TRPV6ALDH1A1 | |
| SCHEMBL20422765 | 0.74 | ORAI1 (0.36) | ORAI1ORAI2ORAI3TRPV6ALDH1A1 | |
| SCHEMBL12318751 | 0.74 | ORAI1 (0.40) | ORAI1ORAI2ORAI3TRPV6ALDH1A1 | |
| SCHEMBL12270863 | 0.72 | TDP1 (0.47) | ORAI1ORAI2ORAI3TRPV6ALDH1A1 | |
| SCHEMBL12319276 | 0.71 | ORAI1 (0.38) | ORAI1ORAI2ORAI3TRPV6ALDH1A1 | |
| SCHEMBL12270776 | 0.70 | TARS1 (0.39) | ORAI1ORAI2ORAI3TRPV6ALDH1A1 | |
| Phenylboronic Acid SCHEMBL23824843 | 0.69 | ENPP2 (0.74) | ORAI1ORAI2ORAI3TRPV6CA4 | |
| Phenylboronic Acid SCHEMBL28944102 | 0.69 | ENPP2 (0.74) | ORAI1ORAI2ORAI3TRPV6CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010018836-A2 | POLYGLUTAMINE AGGREGATION INHIBITOR | 独立行政法人科学技術振興機構 (JP) | 2010-02-18 | — | — | WO | disclosed |
| WO-2010018837-A2 | PROTEIN CROSS-LINKING INHIBITOR | 独立行政法人科学技術振興機構 (JP) | 2010-02-18 | — | — | WO | disclosed |