Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28864240 | 0.71 | ALDH1A1 (0.76) | ALDH1A1POLBKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL203961 | 0.71 | — | — | |
| SCHEMBL20855352 | 0.70 | — | — | |
| SCHEMBL30473912 | 0.69 | ALDH1A1 (0.56) | ALDH1A1POLBKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL30632968 | 0.69 | ALDH1A1 (0.72) | ALDH1A1POLBKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL27795067 | 0.68 | ALDH1A1 (0.82) | ALDH1A1POLBKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL13480988 | 0.68 | KMT2A (0.51) | ALDH1A1POLBKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL30449933 | 0.68 | ALDH1A1 (0.50) | ALDH1A1POLBKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL16372067 | 0.68 | ALDH1A1 (0.54) | ALDH1A1POLBKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL30437353 | 0.68 | ALDH1A1 (0.54) | ALDH1A1POLBKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659312-B2 | Inhibitors of Aquaporin 4, methods and uses thereof | NIIGATA UNIVERSITY (JP) | 2010-02-09 | — | — | US | disclosed |
| US-7659312-B2 | Inhibitors of Aquaporin 4, methods and uses thereof | NIIGATA UNIVERSITY (JP) | 2010-02-09 | — | — | US | disclosed |
| US-20070281978-A1 | INHIBITORS OF AQUAPORIN 4, METHODS AND USES THEREOF | NIIGATA UNIVERSITY (JP) | 2007-12-06 | — | — | US | disclosed |
| US-20070281978-A1 | INHIBITORS OF AQUAPORIN 4, METHODS AND USES THEREOF | NIIGATA UNIVERSITY (JP) | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281978-A1 | INHIBITORS OF AQUAPORIN 4, METHODS AND USES THEREOF | AQP4, AQP1, AQP3 | ALDH1A1 4045/4885POLB 4655/4885KMT2A 3838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.