Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 5/20 | 0.62 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 5/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | STAT3 | P40763 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717597 | 0.83 | MAPT (0.63) | RAB9ASMN1; SMN2MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL18608538 | 0.77 | ALDH1A1 (0.58) | RAB9ASMN1; SMN2MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL18608412 | 0.76 | MAPT (1.00) | RAB9ASMN1; SMN2MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL18608259 | 0.75 | ALDH1A1 (0.65) | RAB9ASMN1; SMN2MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL18608541 | 0.75 | SMN1; SMN2 (0.72) | RAB9ASMN1; SMN2MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL18583110 | 0.75 | ALDH1A1 (0.55) | RAB9ASMN1; SMN2MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL18608639 | 0.73 | RAB9A (0.80) | RAB9ASMN1; SMN2MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL18608250 | 0.73 | SMN1; SMN2 (0.72) | RAB9ASMN1; SMN2MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL18071573 | 0.72 | RAB9A (0.54) | RAB9ASMN1; SMN2MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL18716374 | 0.72 | ALDH1A1 (0.54) | RAB9ASMN1; SMN2MAPTL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100041653-A1 | COMPOSITION AND METHODS FOR THE DESIGN AND DEVELOPMENT OF METALLO-ENZYME INHIBITORS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-02-18 | — | — | US | disclosed |
| US-20100041653-A1 | COMPOSITION AND METHODS FOR THE DESIGN AND DEVELOPMENT OF METALLO-ENZYME INHIBITORS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041653-A1 | COMPOSITION AND METHODS FOR THE DESIGN AND DEVELOPMENT OF METALLO-ENZYME INHIBITORS | HELZ, MMEL1, GAA | RAB9A 1800/4885SMN1; SMN2 3843/4885MAPT 3240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.