R-N-Propylnorapomorphine

R-N-Propylnorapomorphine

SCHEMBL13487203

[11CH3]CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DRD2 P14416 6/20 1.00
▸ DRD3 P35462 5/20 1.00
▸ TH P07101 4/20 1.00
▸ MAPT P10636 4/20 1.00
▸ MAPK1 P28482 4/20 1.00
▸ DRD1 P21728 4/20 1.00
▸ KDM4E B2RXH2 3/20 1.00
▸ LMNA P02545 3/20 1.00
▸ HPGD P15428 3/20 1.00
▸ PMP22 Q01453 3/20 1.00
▸ KMT2A Q03164 3/20 1.00
▸ GMNN O75496 2/20 1.00
▸ GFER P55789 2/20 1.00
▸ SMN1; SMN2 Q16637 2/20 1.00
▸ TDP1 Q9NUW8 2/20 1.00
▸ RGS12 O14924 2/20 1.00
▸ TP53 P04637 2/20 1.00
▸ CYP1A2 P05177 2/20 1.00
▸ CYP2D6 P10635 2/20 1.00
▸ THPO P40225 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
R-N-Propylnorapomorphine SCHEMBL29447877 1.00 DRD2 (1.00) DRD2DRD3THMAPTMAPK1
R-N-Propylnorapomorphine SCHEMBL249729 1.00 DRD2 (1.00) DRD2DRD3THMAPTMAPK1
R-N-Propylnorapomorphine SCHEMBL13398114 1.00 DRD2 (1.00) DRD2DRD3THMAPTMAPK1
R-N-Propylnorapomorphine SCHEMBL7997518 1.00 DRD2 (1.00) DRD2DRD3THMAPTMAPK1
SCHEMBL14161595 0.91 MAPT (0.83) DRD2DRD3THMAPTMAPK1
SCHEMBL1203698 0.90 DRD2 (1.00) DRD2DRD3THMAPTMAPK1
SCHEMBL10754712 0.90 DRD2 (1.00) DRD2DRD3THMAPTMAPK1
SCHEMBL1203699 0.90 DRD2 (1.00) DRD2DRD3THMAPTMAPK1
SCHEMBL19815875 0.89 DRD2 (1.00) DRD2DRD3THMAPTMAPK1
Hydrochloric Acid SCHEMBL10752801 0.88 DRD2 (0.98) DRD2DRD3THMAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100040545-A1 RADIOLABELLING METHODS HAMMERSMITH IMANET LIMITED (GB) 2010-02-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100040545-A1 RADIOLABELLING METHODS NPSR1, SSTR3, SSTR5 DRD2 246/4885DRD3 312/4885TH 752/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback