R-N-Propylnorapomorphine

R-N-Propylnorapomorphine

SCHEMBL249729

CCCN1CCc2cccc3c2C1Cc1ccc(O)c(O)c1-3

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 6/20 1.00
DRD3 P35462 5/20 1.00
TH P07101 4/20 1.00
MAPT P10636 4/20 1.00
MAPK1 P28482 4/20 1.00
DRD1 P21728 4/20 1.00
KDM4E B2RXH2 3/20 1.00
LMNA P02545 3/20 1.00
HPGD P15428 3/20 1.00
PMP22 Q01453 3/20 1.00
KMT2A Q03164 3/20 1.00
GMNN O75496 2/20 1.00
GFER P55789 2/20 1.00
SMN1; SMN2 Q16637 2/20 1.00
TDP1 Q9NUW8 2/20 1.00
RGS12 O14924 2/20 1.00
TP53 P04637 2/20 1.00
CYP1A2 P05177 2/20 1.00
CYP2D6 P10635 2/20 1.00
THPO P40225 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
R-N-Propylnorapomorphine SCHEMBL29447877 1.00 DRD2 (1.00) DRD2DRD3THMAPTMAPK1
R-N-Propylnorapomorphine SCHEMBL13487203 1.00 DRD2 (1.00) DRD2DRD3THMAPTMAPK1
R-N-Propylnorapomorphine SCHEMBL13398114 1.00 DRD2 (1.00) DRD2DRD3THMAPTMAPK1
R-N-Propylnorapomorphine SCHEMBL7997518 1.00 DRD2 (1.00) DRD2DRD3THMAPTMAPK1
SCHEMBL14161595 0.91 MAPT (0.83) DRD2DRD3THMAPTMAPK1
SCHEMBL1203698 0.90 DRD2 (1.00) DRD2DRD3THMAPTMAPK1
SCHEMBL10754712 0.90 DRD2 (1.00) DRD2DRD3THMAPTMAPK1
SCHEMBL1203699 0.90 DRD2 (1.00) DRD2DRD3THMAPTMAPK1
SCHEMBL19815875 0.89 DRD2 (1.00) DRD2DRD3THMAPTMAPK1
Hydrochloric Acid SCHEMBL10752801 0.88 DRD2 (0.98) DRD2DRD3THMAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 320 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4717276-A2 OPHTHALMIC COMPOSITIONS COMPRISING LEVODOPA, AN ANTIOXIDANT AND AN AQUEOUS CARRIER University of Canberra (AU) 2026-04-01 EP claimed
EP-3442516-B1 OPHTHALMIC COMPOSITIONS COMPRISING LEVODOPA, AN ANTIOXIDANT AND AN AQUEOUS CARRIER UNIV CANBERRA (AU) 2025-11-12 EP claimed
WO-2025151884-A1 USE OF GLYCOSAMINOGLYCAN SULFATED POLYSACCHARIDES SUCH AS SODIUM PENTOSAN POLYSULFATE IN COMBINATION WITH PERMEATION AGENTS TO TREAT ALZHEIMER'S DISEASE PARSONS C LOWELL (US) 2025-07-17 WO claimed
CN-112770734-B Inhibition method 堪培拉大学 2024-08-20 CN claimed
EP-4335504-A2 TREATMENT OF MOVEMENT DISORDERS Contera Pharma ApS (DK) 2024-03-13 EP claimed
US-11890266-B2 Ophthalmic compositions including levodopa, an antioxidant and an aqueous carrier UNIVERSITY OF CANBERRA (AU) 2024-02-06 US claimed
EP-3897641-B1 TREATMENT OF MOVEMENT DISORDERS CONTERA PHARMA AS (DK) 2023-11-15 EP claimed
EP-3448379-B1 TREATMENT OF IMPULSIVITY-RELATED DISORDERS UNIV OXFORD INNOVATION LTD (GB) 2023-06-28 EP claimed
EP-4178948-A2 FUNCTIONALIZED ISONITRILES AND PRODUCTS, PREPARATION AND USES THEREOF Universidade de Santiago de Compostela (ES) 2023-05-17 EP claimed
EP-4003348-A1 COMPOUNDS AND METHODS FOR TREATING FIBROTIC PATHOLOGIES Mayo Foundation for Medical Education and Research (US) 2022-06-01 EP claimed
US-20100172916-A1 SUBSTITUTED HYDROXYPHENYLAMINE COMPOUNDS AUSPEX PHARMACEUTICALS, INC. (US) 2010-07-08 US claimed
WO-2010060070-A2 INDOLINONE MODULATORS OF DOPAMINE RECEPTOR AUSPEX PHARMACEUTICALS, INC. (US) 2010-05-27 WO claimed
US-20100130582-A1 INDOLINONE MODULATORS OF DOPAMINE RECEPTOR AUSPEX PHARMACEUTICALS, INC. (US) 2010-05-27 US claimed
WO-2010054286-A2 SUBSTITUTED HYDROXYPHENYLAMINE COMPOUNDS AUSPEX PHARMACEUTICALS, INC. (US) 2010-05-14 WO claimed
WO-2009078034-A2 ORAL DISINTEGRATING TABLETS OF ROPINIROLE HYDROCHLORIDE RUBICON RESEARCH PRIVATE LIMITED (IN) 2009-06-25 WO claimed
US-20090076019-A1 METHODS FOR TREATING NEUROLOGICAL DISORDERS OR DAMAGE MOUNT SINAI HOSPITAL (CA) 2009-03-19 US claimed
US-20070117788-A1 Combination of a dopamine D2-receptor agonist and tiotropium or a derivative therof for treating obstructive airways and other inflammatory diseases BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2007-05-24 US claimed
EP-1397134-A2 COMBINATION OF A DOPAMINE D2-RECEPTOR AGONIST AND TIOTROPIUM OR A DERIVATIVE THEROF FOR TREATING OBSTRUCTIVE AIRWAYS Boehringer Ingelheim Pharma GmbH & Co.KG (DE) 2004-03-17 EP claimed
WO-2002096422-A2 COMBINATION OF A DOPAMINE D2-RECEPTOR AGONIST AND TIOTROPIUM OR A DERIVATIVE THEREOF FOR TREATING OBSTRUCTIVE AIRWAYS BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2002-12-05 WO claimed
WO-1996004910-A1 TREATMENT OF OPIATE WITHDRAWAL SYNDROME HAHNEMANN UNIVERSITY (US) 1996-02-22 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070117788-A1 Combination of a dopamine D2-receptor agonist and tiotropium or a derivative therof for treating obstructive airways and other inflammatory diseases CHRM2, ADRB2, CHRM3 DRD2 33/4885DRD3 39/4885TH 64/4885
US-20100130582-A1 INDOLINONE MODULATORS OF DOPAMINE RECEPTOR HTR2A, HTR3B, MTNR1A DRD2 63/4885DRD3 108/4885TH 411/4885
US-20100172916-A1 SUBSTITUTED HYDROXYPHENYLAMINE COMPOUNDS MC1R, TYR, MITF DRD2 855/4885DRD3 717/4885TH 47/4885
US-11890266-B2 Ophthalmic compositions including levodopa, an antioxidant and an aqueous carrier TTPA, TST, TXN2 DRD2 2171/4885DRD3 1985/4885TH 116/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.