Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 7/20 | 0.40 |
| ▸ | CTSK | P43235 | 6/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15762019 | 0.86 | CTSK (0.52) | CTSSCTSKCTSLCTSBCA1 | |
| SCHEMBL23052291 | 0.83 | CTSS (0.55) | MAPTCTSSCTSKCTSLCTSB | |
| SCHEMBL12572526 | 0.81 | SMN1; SMN2 (0.47) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL4402164 | 0.81 | CYP1A2 (0.38) | MAPTCTSSCTSKCTSLCTSB | |
| SCHEMBL28544565 | 0.80 | CTSS (0.50) | CTSSCTSKCTSLCTSBCA2 | |
| SCHEMBL28544563 | 0.80 | CTSS (0.50) | CTSSCTSKCTSLCTSBCA2 | |
| SCHEMBL13869526 | 0.79 | PTGS1 (0.57) | CTSSCTSKPTGS1GSTK1FNTA | |
| SCHEMBL16501102 | 0.79 | KDM4E (0.45) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL929412 | 0.79 | SMN1; SMN2 (0.45) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL17928933 | 0.78 | MAPT (0.35) | MAPTCTSSCTSKPTGS1GSTK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133141-B2 | Cysteine and cystine bioisosteres to treat schizophrenia and reduce drug cravings | MARQUETTE UNIVERSITY (US) | 2015-09-15 | — | — | US | disclosed |
| US-9133141-B2 | Cysteine and cystine bioisosteres to treat schizophrenia and reduce drug cravings | MARQUETTE UNIVERSITY (US) | 2015-09-15 | — | — | US | disclosed |
| US-20140155440-A1 | CYSTEINE AND CYSTINE BIOISOSTERES TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS | MARQUETTE UNIVERSITY (US) | 2014-06-05 | — | — | US | disclosed |
| US-20140155440-A1 | CYSTEINE AND CYSTINE BIOISOSTERES TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS | MARQUETTE UNIVERSITY (US) | 2014-06-05 | — | — | US | disclosed |
| US-20100048587-A1 | CYSTEINE AND CYSTINE BIOISOSTERES TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS | MARQUETTE UNIVERSITY (US) | 2010-02-25 | — | — | US | disclosed |
| US-20100048587-A1 | CYSTEINE AND CYSTINE BIOISOSTERES TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS | MARQUETTE UNIVERSITY (US) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140155440-A1 | CYSTEINE AND CYSTINE BIOISOSTERES TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS | CTH, CBS, SLC7A11 | KDM4E 3841/4885MAPT 2979/4885THRB 2452/4885 |
| US-20100048587-A1 | CYSTEINE AND CYSTINE BIOISOSTERES TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS | CTH, CBS, SLC7A11 | KDM4E 3841/4885MAPT 2979/4885THRB 2452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.