Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18038885 | 1.00 | AAK1 (0.34) | AAK1CTSKHDAC6CA1CA2 | |
| SCHEMBL74866 | 0.83 | AAK1 (0.36) | AAK1CTSKHDAC6CA1CA2 | |
| SCHEMBL31236399 | 0.81 | CTSK (0.35) | AAK1CTSKHDAC6HDAC1HDAC2 | |
| SCHEMBL5567395 | 0.81 | CA1 (0.35) | AAK1CTSKHDAC6CA1CA2 | |
| SCHEMBL5567390 | 0.81 | CA1 (0.35) | AAK1CTSKHDAC6CA1CA2 | |
| SCHEMBL29439348 | 0.79 | AAK1 (0.36) | AAK1HDAC6CA1CA2CA7 | |
| SCHEMBL17157171 | 0.78 | CYP2D6 (0.33) | AAK1CTSKHDAC6CA1CA2 | |
| SCHEMBL18055001 | 0.78 | AAK1 (0.35) | AAK1HDAC6CA1CA2CA7 | |
| SCHEMBL18055171 | 0.78 | HDAC6 (0.35) | AAK1HDAC6CA1CA2CA7 | |
| SCHEMBL17157167 | 0.78 | CYP2D6 (0.33) | AAK1CTSKHDAC6CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210188906-A1 | TUBULYSIN ANALOGUES AS ANTICANCER AGENTS AND PAYLOADS FOR ANTIBODY-DRUG CONJUGATES AND METHODS OF TREATMENT THEREWITH | WILLIAM MARSH RICE UNIVERSITY (US) | 2021-06-24 | — | — | US | disclosed |
| EP-3261443-B1 | DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | UNIV RICE WILLIAM M (US) | 2021-04-28 | — | — | EP | disclosed |
| US-10808007-B2 | Desacetoxytubulysin H and analogs thereof | WILLIAM MARSH RICE UNIVERSITY (US) | 2020-10-20 | — | — | US | disclosed |
| US-20180127463-A1 | DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2018-05-10 | — | — | US | disclosed |
| US-20180127463-A1 | DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2018-05-10 | — | — | US | disclosed |
| WO-2016138288-A1 | DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2016-09-01 | — | — | WO | disclosed |
| US-20100047841-A1 | SYNTHESIS OF DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2010-02-25 | — | — | US | disclosed |
| US-20100047841-A1 | SYNTHESIS OF DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2010-02-25 | — | — | US | disclosed |
| WO-2008106080-A9 | SYNTHESIS OF DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-11-05 | — | — | WO | disclosed |
| WO-2008106080-A2 | SYNTHESIS OF DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2008-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127463-A1 | DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | REN, MAN2B2, UTS2R | AAK1 2782/4885CTSK 759/4885HDAC6 966/4885 |
| US-20210188906-A1 | TUBULYSIN ANALOGUES AS ANTICANCER AGENTS AND PAYLOADS FOR ANTIBODY-DRUG CONJUGATES AND METHODS OF TREATMENT THEREWITH | TEK, CD2BP2, SDCBP | AAK1 4475/4885CTSK 900/4885HDAC6 360/4885 |
| US-10808007-B2 | Desacetoxytubulysin H and analogs thereof | REN, MAN2B2, UTS2R | AAK1 2782/4885CTSK 759/4885HDAC6 966/4885 |
| US-20100047841-A1 | SYNTHESIS OF DESACETOXYTUBULYSIN H AND ANALOGS THEREOF | XDH, XPA, TPX2 | AAK1 2623/4885CTSK 2560/4885HDAC6 817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.