Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13489848 | 0.92 | SIGMAR1 (0.54) | SIGMAR1POLBKMT2ADRD2SLC6A3 | |
| SCHEMBL13490057 | 0.86 | SLC6A3 (0.60) | SIGMAR1DRD2SLC6A4SLC6A3 | |
| SCHEMBL4367879 | 0.82 | NCF1 (0.60) | HTTTSHRALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL21443482 | 0.78 | EPHX2 (0.67) | HTTTSHRALDH1A1KDM4EEPHX2 | |
| SCHEMBL3211606 | 0.78 | SIGMAR1 (0.69) | SIGMAR1POLBHTTKMT2ADRD2 | |
| SCHEMBL1651281 | 0.78 | SIGMAR1 (0.67) | SIGMAR1POLBHTTKMT2ADRD2 | |
| SCHEMBL27338664 | 0.78 | SIGMAR1 (0.67) | SIGMAR1POLBHTTKMT2ADRD2 | |
| SCHEMBL13489866 | 0.78 | HRH3 (0.64) | SIGMAR1DRD2SLC6A4SLC6A3 | |
| SCHEMBL15317675 | 0.78 | SIGMAR1 (0.70) | SIGMAR1POLBHTTKMT2ADRD2 | |
| SCHEMBL26041218 | 0.78 | SIGMAR1 (0.51) | SIGMAR1POLBHTTKMT2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048891-A1 | METASUBSTITUTED THIAZOLIDINONES, THEIR MANUFACTURE AND USE AS A DRUG | SCHULZE KLAUSE | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048891-A1 | METASUBSTITUTED THIAZOLIDINONES, THEIR MANUFACTURE AND USE AS A DRUG | PLK2, PDXK, PLK4 | SIGMAR1 3611/4885POLB 32/4885HTT 2974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.