Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.62 |
| ▸ | NPC1 | O15118 | 7/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3771751 | 0.81 | RAB9A (0.74) | RAB9ANPC1MAPTKDM4EHSD17B10 | |
| SCHEMBL2175321 | 0.81 | RAB9A (0.69) | RAB9ANPC1MAPTKDM4EHSD17B10 | |
| SCHEMBL10005000 | 0.79 | RAB9A (0.59) | RAB9ANPC1MAPTKDM4EHSD17B10 | |
| SCHEMBL14773948 | 0.77 | RAB9A (1.00) | RAB9ANPC1MAPTKDM4EHSD17B10 | |
| SCHEMBL29510945 | 0.77 | RAB9A (1.00) | RAB9ANPC1MAPTKDM4EHSD17B10 | |
| SCHEMBL4867130 | 0.77 | RAB9A (0.59) | RAB9ANPC1MAPTKDM4EHSD17B10 | |
| SCHEMBL7932793 | 0.76 | RAB9A (0.62) | RAB9ANPC1MAPTKDM4EHSD17B10 | |
| SCHEMBL4004290 | 0.76 | RAB9A (0.62) | RAB9ANPC1MAPTKDM4EHSD17B10 | |
| SCHEMBL30831166 | 0.75 | SMN1; SMN2 (0.49) | RAB9ANPC1MAPTKDM4EHTT | |
| SCHEMBL30831165 | 0.75 | SMN1; SMN2 (0.49) | RAB9ANPC1MAPTKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701691-B2 | Thienopyrimidine compounds | HOFFMAN-LA ROCHE INC. (US) | 2017-07-11 | — | — | US | disclosed |
| EP-2802590-B1 | THIENOPYRIMIDINE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2017-03-01 | — | — | EP | disclosed |
| US-9284278-B2 | Electroluminescent metal complex | BASF SE (DE) | 2016-03-15 | — | — | US | disclosed |
| EP-2802590-A1 | THIENOPYRIMIDINE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2014-11-19 | — | — | EP | disclosed |
| EP-2139907-B1 | ELECTROLUMINESCENT METAL COMPLEX | BASF SE (DE) | 2013-08-14 | — | — | EP | disclosed |
| WO-2013104575-A1 | THIENOPYRIMIDINE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-18 | — | — | WO | disclosed |
| US-20130178460-A1 | THIENOPYRIMIDINE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2013-07-11 | — | — | US | disclosed |
| US-20100044688-A1 | ELECTROLUMINESCENT METAL COMPLEX | CIBA CORPORATION (US) | 2010-02-25 | — | — | US | disclosed |
| US-20100044688-A1 | ELECTROLUMINESCENT METAL COMPLEX | CIBA CORPORATION (US) | 2010-02-25 | — | — | US | disclosed |
| WO-2008098851-A1 | ELECTROLUMINESCENT METAL COMPLEX | BASF SE (CH) | 2008-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178460-A1 | THIENOPYRIMIDINE COMPOUNDS | SYK, BTK, LCK | RAB9A 3298/4885NPC1 4622/4885MAPT 3770/4885 |
| US-20100044688-A1 | ELECTROLUMINESCENT METAL COMPLEX | LDHA, LDHB, NRP1 | RAB9A 4593/4885NPC1 3478/4885MAPT 4595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.