Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | GLS | O94925 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23033352 | 0.85 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2HTTKMT2AMEN1 | |
| SCHEMBL4013471 | 0.79 | KMT2A (0.67) | ALDH1A1MAPTKMT2AMEN1CYP3A4 | |
| SCHEMBL13499547 | 0.78 | MEN1 (0.51) | ALDH1A1SMN1; SMN2HTTKMT2AMEN1 | |
| SCHEMBL23033355 | 0.74 | KMT2A (0.48) | ALDH1A1HTTMAPTKMT2AMEN1 | |
| SCHEMBL29761989 | 0.74 | SLC1A2 (0.69) | ALDH1A1HTTKMT2ACYP3A4CYP3A5 | |
| SCHEMBL5688541 | 0.73 | CACNA2D1 (0.60) | KMT2AMEN1CYP3A4CYP3A5MGLL | |
| SCHEMBL6797094 | 0.73 | KMT2A (0.58) | ALDH1A1MAPTKMT2AMEN1CYP3A4 | |
| SCHEMBL28710689 | 0.73 | KMT2A (0.46) | SMN1; SMN2HTTKMT2AMEN1CYP3A4 | |
| SCHEMBL20456121 | 0.73 | KMT2A (0.46) | ALDH1A1SMN1; SMN2HTTMAPTKMT2A | |
| SCHEMBL3568985 | 0.72 | LMNA (0.60) | ALDH1A1SMN1; SMN2HTTMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7659276-B2 | Melanin concentrating hormone receptor antagonist | AMGEN, INC. (US) | 2010-02-09 | — | — | US | disclosed |
| US-7659276-B2 | Melanin concentrating hormone receptor antagonist | AMGEN, INC. (US) | 2010-02-09 | — | — | US | disclosed |
| US-20090143405-A1 | MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONIST | AMGEN, INC. (US) | 2009-06-04 | — | — | US | disclosed |
| US-20090143405-A1 | MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONIST | AMGEN, INC. (US) | 2009-06-04 | — | — | US | disclosed |
| US-7514438-B2 | Melanin concentrating hormone receptor antagonist | AMGEN, INC. (US) | 2009-04-07 | — | — | US | disclosed |
| US-7514438-B2 | Melanin concentrating hormone receptor antagonist | AMGEN, INC. (US) | 2009-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143405-A1 | MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONIST | MCHR1, MC1R, NPY1R | ALDH1A1 2113/4885SMN1; SMN2 2202/4885HTT 784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.