Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | MIF | P14174 | 1/20 | 0.61 |
| ▸ | GLS | O94925 | 1/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5332558 | 0.83 | ALDH1A1 (0.64) | KMT2AALDH1A1MEN1POLBMIF | |
| SCHEMBL9156058 | 0.83 | ALDH1A1 (0.60) | KMT2AALDH1A1MEN1POLBMIF | |
| SCHEMBL6215399 | 0.83 | NPC1 (0.60) | KMT2AALDH1A1MEN1POLBMIF | |
| SCHEMBL1011592 | 0.81 | POLB (0.68) | KMT2AALDH1A1MEN1POLBMIF | |
| SCHEMBL23966723 | 0.80 | ALDH1A1 (0.60) | KMT2AALDH1A1MEN1POLBMIF | |
| SCHEMBL11865969 | 0.80 | HTT (0.60) | KMT2AALDH1A1MEN1POLBMIF | |
| SCHEMBL17193491 | 0.80 | GLS (0.82) | KMT2AALDH1A1MEN1POLBMIF | |
| SCHEMBL13499905 | 0.79 | CCNE1 (0.65) | KMT2AALDH1A1MEN1POLBMIF | |
| SCHEMBL894206 | 0.79 | RAB9A (0.58) | KMT2AALDH1A1MEN1POLBMIF | |
| SCHEMBL11168806 | 0.79 | KMT2A (0.55) | KMT2AALDH1A1MEN1POLBMIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048543-A1 | PYRIMIDINE COMPOUNDS HAVING TIES (TEK) INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2010-02-25 | — | — | US | disclosed |
| US-20100048543-A1 | PYRIMIDINE COMPOUNDS HAVING TIES (TEK) INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2010-02-25 | — | — | US | disclosed |
| CN-101137652-A | Pyrimidine compounds having tie2 (tek) inhibitory activity | ASTRAZENECA AB (SE) | 2008-03-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048543-A1 | PYRIMIDINE COMPOUNDS HAVING TIES (TEK) INHIBITORY ACTIVITY | TEK, TYMP, TIE1 | KMT2A 815/4885ALDH1A1 2198/4885MEN1 2463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.