Sugi Predict

Sugi Predict / Compounds / SCHEMBL23966723

SCHEMBL23966723

SCHEMBL23966723

CC(C)(C)c1nnc(NC(=O)Oc2ccccc2)s1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 7/20 0.60
▸ MEN1 O00255 2/20 0.60
▸ KMT2A Q03164 2/20 0.60
▸ POLB P06746 1/20 0.60
▸ MIF P14174 1/20 0.60
▸ CYP2C9 P11712 2/20 0.56
▸ CYP2C19 P33261 2/20 0.56
▸ RAB9A P51151 5/20 0.56
▸ NPC1 O15118 4/20 0.56
▸ SMN1; SMN2 Q16637 2/20 0.56
▸ LMNA P02545 2/20 0.56
▸ PKM P14618 1/20 0.56
▸ MAPT P10636 4/20 0.54
▸ PAX8 Q06710 1/20 0.53
▸ CCNE1 P24864 1/20 0.52
▸ CDK2 P24941 1/20 0.52
▸ CDK5 Q00535 1/20 0.52
▸ NPSR1 Q6W5P4 1/20 0.52
▸ CYP1A2 P05177 1/20 0.51
▸ GLS O94925 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11865969 0.86 HTT (0.60) ALDH1A1MEN1KMT2APOLBMIF
SCHEMBL5332558 0.81 ALDH1A1 (0.64) ALDH1A1MEN1KMT2APOLBMIF
SCHEMBL13499907 0.80 KMT2A (0.61) ALDH1A1MEN1KMT2APOLBMIF
SCHEMBL1011592 0.79 POLB (0.68) ALDH1A1MEN1KMT2APOLBMIF
SCHEMBL6215399 0.78 NPC1 (0.60) ALDH1A1MEN1KMT2APOLBMIF
SCHEMBL9156058 0.78 ALDH1A1 (0.60) ALDH1A1MEN1KMT2APOLBMIF
SCHEMBL17193292 0.78 GLS (0.64) ALDH1A1MEN1KMT2APOLBMIF
SCHEMBL11714626 0.77 RAB9A (0.75) ALDH1A1MEN1KMT2APOLBCYP2C9
SCHEMBL11164154 0.76 MAPT (0.56) ALDH1A1MEN1KMT2APOLBMIF
SCHEMBL283195 0.76 CA1 (0.60) ALDH1A1MEN1KMT2APOLBCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12091413-B2 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2024-09-17 — — US disclosed
EP-4146348-B1 INHIBITORS OF NEK7 KINASE HALIA THERAPEUTICS INC (US) 2024-07-03 — — EP disclosed
US-20230416259-A1 INHIBITORS OF NEK7 KINASE HALIA THERAPEUTICS INC (US) 2023-12-28 — — US disclosed
US-11713321-B2 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2023-08-01 — — US disclosed
US-11713321-B2 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2023-08-01 — — US disclosed
US-20230210853-A1 TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME Halia Therapeutics, Inc. 2023-07-06 — — US disclosed
US-20230210853-A1 TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME Halia Therapeutics, Inc. 2023-07-06 — — US disclosed
US-20230203045-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. 2023-06-29 — — US disclosed
US-20230203045-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. 2023-06-29 — — US disclosed
EP-3424924-B1 UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) 2023-05-24 — — EP disclosed
EP-4161933-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. (US) 2023-04-12 — — EP disclosed
CN-115843272-A Inhibitors of NEK7 kinase 哈利亚治疗公司 2023-03-24 — — CN disclosed
EP-4146348-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. (US) 2023-03-15 — — EP disclosed
CN-109071523-B Urea compound, preparation method and medical application thereof 恩瑞生物医药科技（上海）有限公司 2022-05-31 — — CN disclosed
US-20220064173-A1 INHIBITORS OF NEK7 KINASE HALIA THERAPEUTICS INC (US) 2022-03-03 — — US disclosed
WO-2021252488-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. (US) 2021-12-16 — — WO disclosed
WO-2021242505-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. (US) 2021-12-02 — — WO disclosed
US-20210355130-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. 2021-11-18 — — US disclosed
US-11161852-B1 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2021-11-02 — — US disclosed
CN-109071523-A Urea compound, preparation method and medical application thereof 恩瑞生物医药科技（上海）有限公司 2018-12-21 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210355130-A1 INHIBITORS OF NEK7 KINASE NEK7, NEK1, NEK5 ALDH1A1 4354/4885MEN1 1766/4885KMT2A 2554/4885
US-20230203045-A1 INHIBITORS OF NEK7 KINASE NEK7, NEK1, NEK5 ALDH1A1 4327/4885MEN1 1800/4885KMT2A 2881/4885
US-11713321-B2 Inhibitors of NEK7 kinase NEK7, NEK1, NEK5 ALDH1A1 4354/4885MEN1 1766/4885KMT2A 2554/4885
US-12091413-B2 Inhibitors of NEK7 kinase NEK7, NEK1, NEK5 ALDH1A1 4354/4885MEN1 1766/4885KMT2A 2554/4885
US-20230210853-A1 TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME NEK7, NLRP3, NOD1 ALDH1A1 4542/4885MEN1 3098/4885KMT2A 4530/4885
US-11161852-B1 Inhibitors of NEK7 kinase NEK7, NEK1, NEK5 ALDH1A1 4354/4885MEN1 1766/4885KMT2A 2554/4885
US-20230416259-A1 INHIBITORS OF NEK7 KINASE NEK7, NEK1, NEK5 ALDH1A1 4354/4885MEN1 1766/4885KMT2A 2554/4885
US-20220064173-A1 INHIBITORS OF NEK7 KINASE NEK7, NEK1, NEK5 ALDH1A1 4354/4885MEN1 1766/4885KMT2A 2554/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.