Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13508357 | 0.80 | ESR1 (0.39) | LMNAALDH1A1POLBKDM4EMAPT | |
| SCHEMBL13508364 | 0.79 | PPARD (0.56) | PPARD | |
| SCHEMBL3685122 | 0.79 | PPARD (0.56) | PPARD | |
| SCHEMBL13508359 | 0.78 | ESR1 (0.47) | KMT2AALDH1A1POLBMAPK1HTT | |
| SCHEMBL3685186 | 0.78 | ESR1 (0.47) | KMT2AALDH1A1POLBMAPK1HTT | |
| SCHEMBL13508352 | 0.78 | PPARD (0.45) | ALDH1A1POLBSMN1; SMN2TSHRESR1 | |
| SCHEMBL3686617 | 0.78 | PPARD (0.45) | ALDH1A1POLBSMN1; SMN2TSHRESR1 | |
| SCHEMBL13508358 | 0.77 | ESR1 (0.43) | ALDH1A1MAPK1ESR1PPARD | |
| SCHEMBL3686106 | 0.77 | ESR1 (0.43) | ALDH1A1MAPK1ESR1PPARD | |
| SCHEMBL7920720 | 0.74 | ALDH1A1 (0.59) | LMNAKMT2AALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655641-B2 | Sulfonamide derivatives as PPAR modulators | ELI LILLY AND COMPANY (US) | 2010-02-02 | — | — | US | disclosed |