Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 15/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13508488 | 0.84 | PFKFB3 (0.41) | PPARGPPARAPPARDPFKFB3 | |
| SCHEMBL13508500 | 0.83 | PPARG (0.44) | PPARGPKMPPARAPPARD | |
| SCHEMBL13508430 | 0.83 | PPARG (0.47) | PPARGPPARAPPARD | |
| SCHEMBL15110962 | 0.79 | PPARG (0.45) | PPARGPPARAPPARD | |
| SCHEMBL13508467 | 0.77 | PPARG (0.50) | PPARGPKMPPARAALDH1A1PPARD | |
| SCHEMBL3693027 | 0.76 | PKM (0.38) | PKMALDH1A1KDM4EPFKFB3 | |
| SCHEMBL13508496 | 0.74 | CYP1A2 (0.48) | PPARGPKMPPARAPPARD | |
| SCHEMBL13508556 | 0.74 | PTPN7 (0.44) | PPARGPPARAPPARD | |
| SCHEMBL3693301 | 0.70 | ITGB3 (0.39) | PPARGPKMALDH1A1PFKFB3 | |
| SCHEMBL13508489 | 0.69 | CMA1 (0.41) | PPARGPPARAPPARDPFKFB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655641-B2 | Sulfonamide derivatives as PPAR modulators | ELI LILLY AND COMPANY (US) | 2010-02-02 | — | — | US | disclosed |
| US-7655641-B2 | Sulfonamide derivatives as PPAR modulators | ELI LILLY AND COMPANY (US) | 2010-02-02 | — | — | US | disclosed |