Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.41 |
| ▸ | USP2 | O75604 | 5/20 | 0.40 |
| ▸ | CASP1 | P29466 | 5/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CASP7 | P55210 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13509083 | 0.84 | ALDH1A1 (0.43) | ALDH1A1CYP1A2HSD17B10MAPK1CYP3A4 | |
| SCHEMBL8205476 | 0.84 | ALDH1A1 (0.48) | ALDH1A1CYP1A2HSD17B10MAPK1CYP3A4 | |
| SCHEMBL13510715 | 0.82 | KDR (0.46) | HSD17B10HPGDMEN1KMT2AGRM5 | |
| SCHEMBL13243234 | 0.81 | KMT2A (0.47) | ALDH1A1HSD17B10MAPK1USP2CASP1 | |
| SCHEMBL13510724 | 0.79 | KDM4E (0.57) | ALDH1A1MEN1KMT2AMAPTATM | |
| SCHEMBL17280145 | 0.74 | CASP1 (0.42) | ALDH1A1HSD17B10MAPK1USP2CASP1 | |
| SCHEMBL13510688 | 0.72 | LTA4H (0.47) | ALDH1A1MAPTATMTSHRLMNA | |
| SCHEMBL13510722 | 0.72 | GABRA5 (0.37) | ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14294733 | 0.71 | NR1H2 (0.54) | ALDH1A1CYP1A2MAPK1CYP3A4CYP2C9 | |
| SCHEMBL16225052 | 0.71 | ALOX5AP (0.49) | ALDH1A1CYP1A2HSD17B10CASP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662779-B2 | Triazolyl macrocyclic hepatitis C serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2010-02-16 | — | — | US | disclosed |
| US-20090047248-A1 | TRIAZOLYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090047248-A1 | TRIAZOLYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | SPINT2, PRSS1, CTSC | ALDH1A1 1237/4885CYP1A2 261/4885HSD17B10 770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.