Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.64 |
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | AR | P10275 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 10/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.54 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12840718 | 0.88 | RAB9A (0.64) | RAB9ANPC1ARMEN1KMT2A | |
| SCHEMBL21005885 | 0.84 | MPL (0.66) | RAB9ANPC1ARMEN1KMT2A | |
| SCHEMBL8172023 | 0.81 | RAB9A (0.70) | RAB9ANPC1ARMEN1KMT2A | |
| SCHEMBL16254980 | 0.81 | ABL1 (0.79) | RAB9ANPC1MEN1KMT2APSMD14 | |
| SCHEMBL12881839 | 0.79 | MAPT (0.62) | RAB9ANPC1ARMEN1KMT2A | |
| SCHEMBL1764691 | 0.78 | ALDH1A1 (0.60) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL8171460 | 0.78 | MAPT (0.74) | RAB9ANPC1ARMEN1KMT2A | |
| SCHEMBL14048212 | 0.78 | NPC1 (1.00) | RAB9ANPC1ARMEN1KMT2A | |
| SCHEMBL23742674 | 0.78 | MEN1 (0.57) | RAB9ANPC1MEN1KMT2APSMD14 | |
| SCHEMBL7109635 | 0.78 | ALOX5 (0.74) | MEN1KMT2AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575502-B1 | COMPOSITIONS AND METHODS INVOLVING NUCLEAR HORMONE RECEPTOR SITE II | BRISTOL MYERS SQUIBB CO (US) | 2010-01-20 | — | — | EP | disclosed |
| US-7442554-B2 | Compositions and methods involving glucocorticoid receptor site II | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-10-28 | — | — | US | disclosed |