Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 8/20 | 0.74 |
| ▸ | CYP1A1 | P04798 | 7/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.61 |
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.61 |
| ▸ | VCP | P55072 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.52 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.52 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7115739 | 0.87 | ALOX5 (0.81) | ALOX5CYP1A1CYP1A2CYP1B1VCP | |
| SCHEMBL7113187 | 0.85 | ALOX5 (0.65) | ALOX5VCPMEN1DEGS1MAP4K4 | |
| SCHEMBL7116150 | 0.82 | ALOX5 (0.52) | ALOX5VCPMEN1DEGS1MAP4K4 | |
| SCHEMBL12298054 | 0.82 | CYP1A1 (0.82) | ALOX5CYP1A1CYP1A2CYP1B1VCP | |
| SCHEMBL28701564 | 0.82 | CYP1B1 (0.77) | ALOX5CYP1A1CYP1A2CYP1B1MAPT | |
| SCHEMBL7246864 | 0.81 | ALOX5 (0.79) | ALOX5CYP1A1CYP1A2CYP1B1VCP | |
| SCHEMBL12157973 | 0.80 | ALOX5 (0.73) | ALOX5VCPMEN1AMY1AMAPT | |
| SCHEMBL28117072 | 0.80 | MEN1 (0.64) | ALOX5CYP1A1CYP1A2CYP1B1MEN1 | |
| SCHEMBL12157914 | 0.79 | MPL (0.56) | ALOX5VCPMEN1AMY1AMAPT | |
| SCHEMBL7153995 | 0.79 | ALOX5 (0.62) | ALOX5CYP1A1CYP1A2CYP1B1VCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030220380-A1 | Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-11-27 | — | — | US | claimed |
| US-6586453-B2 | Useful in prophylaxis or treatment of thrombosis, angina, pectoris, cerebral infarction, myocardial/pulmonary infarction, intra-atrial thrombus in atrial fibrillation, diabetic complications, restenosis, and stroke | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-07-01 | — | — | US | claimed |
| US-20010044545-A1 | Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2001-11-22 | — | — | US | claimed |
| US-20030220380-A1 | Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-11-27 | — | — | US | disclosed |
| WO-2001074793-A2 | SUBSTITUTED THIAZOLES AND THE USE THEREOF AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010044545-A1 | Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 | SERPINE1, SERPINC1, SERPINB1 | ALOX5 2040/4885CYP1A1 669/4885CYP1A2 1458/4885 |
| US-20030220380-A1 | Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 | SERPINE1, SERPINC1, SERPINB1 | ALOX5 2040/4885CYP1A1 669/4885CYP1A2 1458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.