Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RGS4 | P49798 | 10/20 | 1.00 |
| ▸ | RGS8 | P57771 | 9/20 | 1.00 |
| ▸ | GSK3B | P49841 | 9/20 | 0.61 |
| ▸ | GSK3A | P49840 | 6/20 | 0.61 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13739816 | 0.77 | RGS4 (0.63) | RGS4RGS8GSK3BGSK3A | |
| SCHEMBL13517588 | 0.70 | RGS4 (1.00) | RGS4RGS8GSK3BGSK3APRKCA | |
| SCHEMBL18691723 | 0.70 | GSK3B (0.67) | RGS4RGS8GSK3BGSK3APRKCA | |
| SCHEMBL13562489 | 0.69 | RGS4 (0.73) | RGS4RGS8GSK3BGSK3APRKCA | |
| SCHEMBL5023672 | 0.69 | — | — | |
| SCHEMBL13517328 | 0.69 | RGS4 (1.00) | RGS4RGS8GSK3BGSK3APRKCA | |
| SCHEMBL13562487 | 0.68 | RGS4 (0.81) | RGS4RGS8GSK3BGSK3APRKCA | |
| SCHEMBL3381333 | 0.67 | GSK3B (1.00) | RGS4RGS8GSK3BGSK3APRKCA | |
| SCHEMBL13562484 | 0.67 | RGS4 (0.68) | RGS4RGS8GSK3BGSK3APRKCA | |
| SCHEMBL6015126 | 0.66 | GSK3B (1.00) | RGS4RGS8GSK3BGSK3APRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865750-B2 | Small molecule inhibitors of RGS proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-10-21 | — | — | US | disclosed |
| US-8865750-B2 | Small molecule inhibitors of RGS proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-10-21 | — | — | US | disclosed |
| US-8865750-B2 | Small molecule inhibitors of RGS proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-10-21 | — | — | US | disclosed |
| WO-2012149335-A2 | SMALL MOLECULE INHIBITORS OF RGS PROTEINS | NEUBIG RICHARD (US) | 2012-11-01 | — | — | WO | disclosed |
| US-20120277273-A1 | SMALL MOLECULE INHIBITORS OF RGS PROTEINS | THE UNIVERSITY OF BATH (GB) | 2012-11-01 | — | — | US | disclosed |
| US-20120277273-A1 | SMALL MOLECULE INHIBITORS OF RGS PROTEINS | THE UNIVERSITY OF BATH (GB) | 2012-11-01 | — | — | US | disclosed |
| US-20120277273-A1 | SMALL MOLECULE INHIBITORS OF RGS PROTEINS | THE UNIVERSITY OF BATH (GB) | 2012-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277273-A1 | SMALL MOLECULE INHIBITORS OF RGS PROTEINS | RGS4, RGS16, RGS12 | RGS4 1/4885RGS8 4/4885GSK3B 245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.