Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Carbazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | KIF11 | P52732 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | TDO2 | P48775 | 1/20 | 0.52 |
| ▸ | GPR3 | P46089 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721261 | 0.83 | KMT2A (0.50) | EGFRSRCPTGS2ALDH1A1IDO1 | |
| SCHEMBL9225081 | 0.81 | CDK1 (0.57) | KIF11ALDH1A1GPR3HSD17B10MEN1 | |
| Benzene SCHEMBL28024147 | 0.79 | CDK1 (0.56) | KIF11ALDH1A1GPR3HSD17B10KMT2A | |
| SCHEMBL9221704 | 0.79 | CDK1 (0.56) | KIF11ALDH1A1GPR3HSD17B10MEN1 | |
| Toluene SCHEMBL180606 | 0.79 | SMN1; SMN2 (0.65) | ALDH1A1POLBTDP1SMN1; SMN2KDM4E | |
| SCHEMBL932442 | 0.79 | SMN1; SMN2 (0.73) | ALDH1A1POLBTDP1SMN1; SMN2KDM4E | |
| SCHEMBL13836876 | 0.79 | SMN1; SMN2 (0.73) | ALDH1A1POLBTDP1SMN1; SMN2KDM4E | |
| Carbazole SCHEMBL10650068 | 0.79 | ALDH1A1 (0.70) | KIF11ALDH1A1IDO1TDO2GPR3 | |
| Carbazole SCHEMBL742559 | 0.79 | ALDH1A1 (0.70) | KIF11ALDH1A1IDO1TDO2GPR3 | |
| Benzene SCHEMBL5085625 | 0.79 | SMN1; SMN2 (0.64) | ALDH1A1POLBTDP1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110287365-A1 | LITHOGRAPHIC PRINTING PLATE PRECURSORS | CITICORP NORTH AMERICA, INC., AS AGENT | 2011-11-24 | — | — | US | disclosed |
| WO-2011146548-A1 | LITHOGRAPHIC PRINTING PLATE PRECURSORS AND A METHOD OF PROVIDING A LITHOGRAPHIC PRINTING PLATE | EASTMAN KODAK COMPANY (US) | 2011-11-24 | — | — | WO | disclosed |