Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.46 |
| ▸ | KDM6A | O15550 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13522999 | 0.83 | MAPT (0.64) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL13522986 | 0.81 | NPC1 (0.69) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL13522994 | 0.80 | NPC1 (0.57) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9868781 | 0.79 | MAPT (0.61) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL13522796 | 0.78 | KDM6B (0.73) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL13522988 | 0.78 | SGMS2 (0.53) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9868181 | 0.76 | NPC1 (0.71) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9867464 | 0.75 | KDM4E (0.68) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6759895 | 0.74 | MAPT (0.45) | SMN1; SMN2MAPTHPGDMEN1KMT2A | |
| SCHEMBL6762328 | 0.73 | MAOA (0.48) | NPC1RAB9AALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642358-B2 | Substituted phenylacetic acids | METABOLEX, INC. (US) | 2010-01-05 | — | — | US | disclosed |
| US-7642358-B2 | Substituted phenylacetic acids | METABOLEX, INC. (US) | 2010-01-05 | — | — | US | disclosed |