Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | HMGCR | P04035 | 11/20 | 0.49 |
| ▸ | RXRA | P19793 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13847325 | 0.85 | HMGCR (0.66) | HMGCR | |
| SCHEMBL13847624 | 0.78 | HMGCR (0.66) | HMGCR | |
| SCHEMBL247234 | 0.72 | HMGCR (0.74) | HMGCRRXRA | |
| SCHEMBL247233 | 0.72 | HMGCR (0.74) | HMGCRRXRA | |
| SCHEMBL7481306 | 0.72 | HMGCR (0.74) | HMGCRRXRA | |
| SCHEMBL7481310 | 0.72 | HMGCR (0.74) | HMGCRRXRA | |
| SCHEMBL9301248 | 0.72 | HMGCR (0.74) | HMGCRRXRA | |
| SCHEMBL13994086 | 0.71 | HMGCR (0.61) | HMGCR | |
| SCHEMBL9031227 | 0.69 | NR4A2 (0.81) | NR1I2NR4A2PDE4DHMGCRRXRA | |
| SCHEMBL14262699 | 0.69 | NR4A2 (0.81) | NR1I2NR4A2PDE4DHMGCRRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645747-B2 | Improved pharmacokinetic properties, oral bioavailability; side effect reduction | GILEAD SCIENCES, INC. (US) | 2010-01-12 | — | — | US | disclosed |