Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | ALB | P02768 | 5/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | SMO | Q99835 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20198792 | 0.88 | PTGS2 (0.41) | CYP51A1CA1CA2CA5ACA9 | |
| SCHEMBL16479570 | 0.81 | CYP3A4 (0.49) | CA2TP53PTGS2CNR1CYP3A4 | |
| SCHEMBL28465669 | 0.79 | PTGS2 (0.52) | TP53PTGS2CNR1CYP3A4CYP2D6 | |
| SCHEMBL14394949 | 0.79 | CYP3A4 (0.49) | CYP51A1CA1CA2TP53PTGS2 | |
| SCHEMBL30874461 | 0.78 | CYP51A1 (0.49) | CYP51A1CA1CA2CA5ACA9 | |
| SCHEMBL14945526 | 0.77 | ESR1 (0.47) | CYP51A1CA1CA2CA5ACA9 | |
| SCHEMBL13526996 | 0.77 | PPARA (0.44) | CA1CA2CA5ACA9CA5B | |
| SCHEMBL14080289 | 0.75 | TP53 (0.43) | CYP51A1CA1CA2CA5ACA9 | |
| SCHEMBL15290259 | 0.74 | PTGS2 (0.44) | CYP51A1CA1CA2CA5ACA9 | |
| SCHEMBL28679219 | 0.74 | KCNH2 (0.41) | TP53PTGS2KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170349621-A1 | TRIAZOLE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | BioVersys AG (CH) | 2017-12-07 | — | — | US | disclosed |
| US-20160152654-A1 | TRIAZOLE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | BioVersys AG (CH) | 2016-06-02 | — | — | US | disclosed |
| US-9085600-B2 | Triazole compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-07-21 | — | — | US | disclosed |
| US-20140094422-A1 | Triazole Compounds and Methods of Making and Using the Same | SILICON VALLEY BANK | 2014-04-03 | — | — | US | disclosed |
| US-8470985-B2 | Triazole compounds and methods of making and using the same | RIB-X PHARMACEUTICALS, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20100016955-A1 | Triazole compounds and methods of making and using the same | BioVersys AG (CH) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016955-A1 | Triazole compounds and methods of making and using the same | IL33, PROKR1, VIP | CYP51A1 28/4885CA1 3327/4885CA2 3823/4885 |
| US-20170349621-A1 | TRIAZOLE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | PROKR1, ARG1, ARG2 | CYP51A1 19/4885CA1 3502/4885CA2 3747/4885 |
| US-20140094422-A1 | Triazole Compounds and Methods of Making and Using the Same | PROKR1, ARG1, ARG2 | CYP51A1 19/4885CA1 3502/4885CA2 3747/4885 |
| US-20160152654-A1 | TRIAZOLE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | PROKR1, ARG1, ARG2 | CYP51A1 19/4885CA1 3502/4885CA2 3747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.