Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.51 |
| ▸ | AGER | Q15109 | 3/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10722280 | 0.94 | HSD11B1 (0.70) | LMNANPC1RAB9AHSD11B1ADORA2A | |
| SCHEMBL96038 | 0.86 | HSD11B1 (0.62) | LMNANPC1RAB9AHSD11B1ADORA2A | |
| SCHEMBL4486060 | 0.86 | HSD11B1 (0.61) | LMNANPC1RAB9AHSD11B1ADORA2A | |
| SCHEMBL4139952 | 0.86 | L3MBTL1 (0.62) | LMNAHSD11B1ADORA2AAGERMTNR1A | |
| SCHEMBL1356197 | 0.84 | HSD11B1 (0.60) | LMNANPC1RAB9AHSD11B1ADORA2A | |
| SCHEMBL1354645 | 0.83 | HSD11B1 (0.53) | LMNANPC1RAB9AHSD11B1ADORA2A | |
| SCHEMBL1354666 | 0.82 | ADORA2A (0.61) | LMNANPC1RAB9AHSD11B1ADORA2A | |
| SCHEMBL10720234 | 0.81 | HSD11B1 (0.56) | LMNANPC1RAB9AHSD11B1AGER | |
| SCHEMBL1355162 | 0.81 | TSHR (0.53) | LMNANPC1RAB9AHSD11B1ADORA2A | |
| SCHEMBL1354697 | 0.81 | HSD11B1 (0.54) | LMNANPC1RAB9AHSD11B1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029393-B2 | Adenosine receptor ligands and uses thereof | KALDI PHARMA, SAS (FR) | 2015-05-12 | — | — | US | disclosed |
| CN-102365280-B | adenosine receptor ligands and uses thereof | DOMAIN THERAPEUTICS (FR) | 2014-10-29 | — | — | CN | disclosed |
| EP-2391625-B1 | New adenosine receptor ligands and uses thereof | DOMAIN THERAPEUTICS (FR) | 2013-05-01 | — | — | EP | disclosed |
| EP-2391625-A1 | NEW ADENOSINE RECEPTOR LIGANDS AND USES THEREOF | Domain Therapeutics (FR) | 2011-12-07 | — | — | EP | disclosed |
| US-20110288074-A1 | NEW ADENOSINE RECEPTOR LIGANDS AND USES THEREOF | DOMAIN THERAPEUTICS (FR) | 2011-11-24 | — | — | US | disclosed |
| WO-2010084425-A1 | NEW ADENOSINE RECEPTOR LIGANDS AND USES THEREOF | DOMAIN THERAPEUTICS (FR) | 2010-07-29 | — | — | WO | disclosed |
| EP-2210891-A1 | New adenosine receptor ligands and uses thereof | Domain Therapeutics (FR) | 2010-07-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288074-A1 | NEW ADENOSINE RECEPTOR LIGANDS AND USES THEREOF | ADORA2A, ADORA1, ADORA2B | LMNA 3802/4885NPC1 1152/4885RAB9A 1899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.