Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 7/20 | 0.39 |
| ▸ | ACE | P12821 | 4/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14599866 | 1.00 | MME (0.39) | MMEACECA2CTRB1PSMB1 | |
| SCHEMBL8769837 | 0.87 | CTRB1 (0.48) | CA2CTRB1PSMB1PSMB5PSMB2 | |
| SCHEMBL2059402 | 0.81 | ATM (0.57) | ACE | |
| SCHEMBL8947270 | 0.81 | ATM (0.57) | ACE | |
| SCHEMBL8481817 | 0.81 | ATM (0.57) | ACE | |
| SCHEMBL3105737 | 0.79 | LTA4H (0.46) | MMEACE | |
| SCHEMBL13535097 | 0.79 | TRPA1 (0.51) | MMEACECYP3A4MAPK1 | |
| SCHEMBL13535103 | 0.79 | SLC15A1 (0.44) | MMEACECTRB1 | |
| SCHEMBL4960427 | 0.77 | MME (0.46) | MMEACECA2CYP3A4 | |
| SCHEMBL3798364 | 0.77 | MME (0.46) | MMEACECA2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7649015-B2 | Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2010-01-19 | — | — | US | disclosed |