Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 6/20 | 0.43 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22227949 | 0.81 | P4HTM (0.55) | KDRP4HTMNPC1ALDH1A1GAA | |
| SCHEMBL22854273 | 0.79 | NPC1 (0.45) | KDRP4HTMPIP5K1CPIK3CAPI4KA | |
| SCHEMBL20416193 | 0.76 | TGM2 (0.50) | KDRP4HTMNPC1ALDH1A1GAA | |
| SCHEMBL30602659 | 0.74 | NAMPT (0.51) | KDRP4HTMSMN1; SMN2NAMPT | |
| SCHEMBL20828515 | 0.74 | NAMPT (0.51) | KDRP4HTMSMN1; SMN2NAMPT | |
| SCHEMBL4314837 | 0.73 | NPC1 (0.41) | KDRP4HTMPIP5K1CPIK3CAPI4KA | |
| SCHEMBL25692287 | 0.73 | MAOB (0.50) | KDRP4HTMPIP5K1CPIK3CAPI4KA | |
| SCHEMBL428478 | 0.72 | NPC1 (0.49) | KDRP4HTMPIP5K1CPIK3CAPI4KA | |
| SCHEMBL2642966 | 0.72 | PIP5K1C (0.49) | PIP5K1CPIK3CAPI4KAPI4KBNPC1 | |
| SCHEMBL18146372 | 0.72 | CSF1R (0.47) | KDRP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |