Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.39 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.36 |
| ▸ | HTR3B | O95264 | 4/20 | 0.36 |
| ▸ | HTR3A | P46098 | 4/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP4 | P49662 | 1/20 | 0.35 |
| ▸ | CASP5 | P51878 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359363 | 0.74 | HRH3 (0.38) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL31339576 | 0.71 | ADRB2 (0.37) | ADRB2ADRB1PLD1ALDH1A1KDM4E | |
| SCHEMBL17734063 | 0.71 | ADRB2 (0.39) | ADRB2ADRB1PLD1ALDH1A1KDM4E | |
| SCHEMBL8151248 | 0.69 | CASP6 (0.42) | ALDH1A1KDM4ENCF1SMN1; SMN2TDP1 | |
| SCHEMBL10273036 | 0.61 | — | — | |
| SCHEMBL712689 | 0.61 | ADRB1 (0.38) | ADRB2ADRB1PLD1ALDH1A1KDM4E | |
| SCHEMBL25140500 | 0.58 | SCN4A (0.37) | ADRB2ADRB1PLD1ALDH1A1KDM4E | |
| SCHEMBL1229731 | 0.58 | HRH1 (0.85) | ADRB2ADRB1PLD1ALDH1A1KDM4E | |
| SCHEMBL15748040 | 0.58 | HRH1 (0.61) | ADRB2ADRB1PLD1ALDH1A1KDM4E | |
| SCHEMBL5570604 | 0.58 | ADRB1 (0.77) | ADRB2ADRB1PLD1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2140864-A2 | Use of GAL3 receptor antagonists for the treatment of depression and / or anxiety and compounds useful in such methods | H.Lundbeck A/S (DK) | 2010-01-06 | — | — | EP | disclosed |