Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP5 | P51878 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6791357 | 0.91 | SIGMAR1 (0.45) | MAPTUSP2MEN1XBP1KMT2A | |
| SCHEMBL6795876 | 0.90 | MAPT (0.51) | MAPTUSP2MEN1XBP1KMT2A | |
| SCHEMBL8095257 | 0.87 | ACHE (0.51) | MAPTMEN1KMT2ACASP1CASP5 | |
| SCHEMBL3246483 | 0.86 | NPY2R (0.41) | MAPTUSP2MEN1XBP1KMT2A | |
| SCHEMBL6789057 | 0.85 | LMNA (0.51) | MAPTCASP1CASP5GAAACHE | |
| SCHEMBL6790642 | 0.85 | LMNA (0.47) | MAPTUSP2CASP1CASP5GAA | |
| SCHEMBL6784851 | 0.85 | CASP1 (0.46) | MAPTCASP1CASP5GAAACHE | |
| SCHEMBL6784463 | 0.84 | HTR2C (0.56) | MEN1KMT2ACASP1CASP5GAA | |
| SCHEMBL6788475 | 0.83 | CASP1 (0.45) | MAPTCASP1CASP5GAAACHE | |
| SCHEMBL13552258 | 0.83 | HTR2C (0.46) | MAPTCASP1CASP5GAAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2140864-A2 | Use of GAL3 receptor antagonists for the treatment of depression and / or anxiety and compounds useful in such methods | H.Lundbeck A/S (DK) | 2010-01-06 | — | — | EP | disclosed |