Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 12/20 | 0.54 |
| ▸ | CCND1 | P24385 | 5/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.54 |
| ▸ | CDK2 | P24941 | 3/20 | 0.54 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.52 |
| ▸ | CCND3 | P30281 | 3/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.50 |
| ▸ | CCND2 | P30279 | 2/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.50 |
| ▸ | STAT6 | P42226 | 2/20 | 0.49 |
| ▸ | WEE1 | P30291 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1355881 | 0.89 | STAT6 (0.57) | CDK4CCND1CCNA2CDK2CDK6 | |
| SCHEMBL1355286 | 0.89 | CDK4 (0.59) | CDK4CCND1CCNA2CDK2CCND3 | |
| SCHEMBL344502 | 0.87 | CDK4 (0.60) | CDK4CCND1CCNA2CDK2CDK6 | |
| SCHEMBL3588808 | 0.85 | CDK4 (0.54) | CDK4CCND1CCNA2CDK2CDK6 | |
| SCHEMBL3587747 | 0.82 | CDK4 (0.51) | CDK4CCND1CCNA2CDK2CDK6 | |
| SCHEMBL16513553 | 0.80 | JUN (0.66) | CDK4CCND1CCNA2CDK2CDK6 | |
| SCHEMBL1353745 | 0.79 | AURKA (0.53) | JAK2 | |
| SCHEMBL1353701 | 0.77 | EIF2AK4 (0.60) | CDK4CCND1CCNA2CDK2CDK6 | |
| SCHEMBL1353795 | 0.77 | DCLK1 (0.52) | CDK4CCND1CCNA2CDK2CCND3 | |
| SCHEMBL1353817 | 0.77 | CDK4 (0.36) | CDK4CCND1CCNA2CDK2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110281821-A9 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2011-11-17 | — | — | US | claimed |
| US-20100249067-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2010-09-30 | — | — | US | claimed |
| US-20110281821-A9 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2011-11-17 | — | — | US | disclosed |
| US-20100249067-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249067-A1 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | CDK4 101/4885CCND1 160/4885CCNA2 138/4885 |
| US-20110281821-A9 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | CDK4 101/4885CCND1 160/4885CCNA2 138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.