Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.34 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11946810 | 0.79 | HRH3 (0.42) | JAK2JAK3JAK1TYK2HRH3 | |
| SCHEMBL986124 | 0.79 | CHRNB2 (0.36) | JAK2JAK3JAK1TYK2HRH3 | |
| SCHEMBL17793165 | 0.77 | HRH3 (0.41) | JAK2JAK3JAK1TYK2HRH3 | |
| SCHEMBL2581848 | 0.77 | TERT (0.38) | JAK2JAK3JAK1TYK2HRH3 | |
| SCHEMBL17789616 | 0.76 | MEN1 (0.43) | JAK2JAK3JAK1TYK2SIGMAR1 | |
| SCHEMBL10263495 | 0.76 | HRH3 (0.46) | JAK2JAK3JAK1TYK2HRH3 | |
| SCHEMBL1703040 | 0.75 | SIGMAR1 (0.41) | JAK2JAK3JAK1TYK2HRH3 | |
| SCHEMBL10203212 | 0.75 | KDM4E (0.43) | JAK2JAK3JAK1TYK2HRH3 | |
| SCHEMBL10141504 | 0.75 | MEN1 (0.42) | JAK2JAK3JAK1TYK2SIGMAR1 | |
| SCHEMBL19267190 | 0.74 | PSMB1 (0.34) | JAK2JAK3JAK1TYK2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010000364-A1 | PYRROLOPYRIDINYLPYRIMIDIN-2-YLAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-01-07 | — | — | WO | disclosed |