Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.68 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11441218 | 0.83 | MAPT (0.74) | MAPTMCOLN3CA12CA9LMNA | |
| SCHEMBL2008337 | 0.82 | MAPT (1.00) | MAPTMCOLN3CA12CA9LMNA | |
| SCHEMBL9319395 | 0.82 | MAPT (0.72) | MAPTMCOLN3CA12CA9LMNA | |
| SCHEMBL27482139 | 0.82 | TP53 (0.54) | MAPTMCOLN3LMNAMEN1KMT2A | |
| SCHEMBL15480590 | 0.79 | MAPT (0.68) | MAPTMCOLN3CA12CA9LMNA | |
| SCHEMBL13543251 | 0.79 | SMN1; SMN2 (0.51) | MAPTLMNAHTTNPSR1L3MBTL1 | |
| SCHEMBL6302212 | 0.78 | MAPT (0.82) | MAPTMCOLN3CA12CA9LMNA | |
| SCHEMBL18031174 | 0.78 | MAPT (0.82) | MAPTMCOLN3CA12CA9LMNA | |
| SCHEMBL1701967 | 0.77 | CA2 (0.57) | MAPTLMNAMEN1KMT2AHTT | |
| SCHEMBL24125059 | 0.74 | MAPT (0.82) | MAPTMCOLN3CA12CA9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |