Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2B | Q14289 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | IDH2 | P48735 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | ACLY | P53396 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13543309 | 0.86 | MAPT (0.43) | PTK2BSMN1; SMN2MAPTTP53LMNA | |
| SCHEMBL13543501 | 0.84 | POLB (0.57) | SMN1; SMN2MAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL21626414 | 0.81 | MAPT (0.53) | SMN1; SMN2MAPTTP53LMNAHTT | |
| SCHEMBL26144894 | 0.78 | PTK2B (0.62) | PTK2BSMN1; SMN2MAPTTP53LMNA | |
| SCHEMBL1018953 | 0.77 | MEP1B (0.58) | IDH2L3MBTL1 | |
| SCHEMBL18574475 | 0.77 | PTK2B (0.66) | PTK2BSMN1; SMN2MAPTTP53LMNA | |
| SCHEMBL3525958 | 0.75 | ATM (0.51) | PTK2BSMN1; SMN2LMNAIDH2POLB | |
| SCHEMBL3532645 | 0.75 | NPSR1 (0.65) | PTK2BSMN1; SMN2MAPTPOLBACLY | |
| SCHEMBL2542954 | 0.74 | IDH2 (0.52) | MAPTTP53LMNAIDH2POLB | |
| SCHEMBL17465671 | 0.73 | PTK2B (0.57) | PTK2BSMN1; SMN2MAPTTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |