Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13543314 | 0.86 | PIK3CD (0.48) | POLBL3MBTL1TDP1HSD17B10KDM4E | |
| SCHEMBL13543493 | 0.84 | PTK2B (0.58) | POLBL3MBTL1TDP1HTTSMN1; SMN2 | |
| SCHEMBL9436722 | 0.79 | POLB (0.58) | POLBL3MBTL1TDP1HSD17B10KDM4E | |
| SCHEMBL11710429 | 0.78 | POLB (0.57) | POLBL3MBTL1TDP1HSD17B10KDM4E | |
| SCHEMBL18723228 | 0.78 | POLB (0.75) | POLBL3MBTL1TDP1HSD17B10HTT | |
| SCHEMBL8067660 | 0.77 | POLB (0.62) | POLBL3MBTL1TDP1HSD17B10KDM4E | |
| SCHEMBL13544479 | 0.77 | ATM (0.51) | POLBTDP1HSD17B10KMT2AMEN1 | |
| SCHEMBL11595503 | 0.77 | POLB (0.56) | POLBL3MBTL1TDP1HSD17B10KDM4E | |
| SCHEMBL11595561 | 0.77 | POLB (0.62) | POLBL3MBTL1TDP1HSD17B10KDM4E | |
| SCHEMBL1018953 | 0.76 | MEP1B (0.58) | L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |