Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.43 |
| ▸ | TP53 | P04637 | 9/20 | 0.43 |
| ▸ | LMNA | P02545 | 9/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | IDH2 | P48735 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13543493 | 0.86 | PTK2B (0.58) | MAPTTP53LMNAPTK2BSMN1; SMN2 | |
| SCHEMBL13543314 | 0.85 | PIK3CD (0.48) | MAPTSMN1; SMN2IDH2MEN1KMT2A | |
| SCHEMBL21626414 | 0.79 | MAPT (0.53) | MAPTTP53LMNASMN1; SMN2MEN1 | |
| SCHEMBL13542967 | 0.78 | ALDH1A1 (0.36) | LMNAIDH2TDP1 | |
| SCHEMBL13542963 | 0.77 | IDH2 (0.47) | MAPTIDH2MAPK1 | |
| SCHEMBL13542942 | 0.76 | ATM (0.40) | MAPTLMNASMN1; SMN2IDH2MEN1 | |
| SCHEMBL13543501 | 0.71 | POLB (0.57) | MAPTSMN1; SMN2MEN1MAPK1HTT | |
| SCHEMBL13543170 | 0.70 | CES2 (0.59) | LMNAMEN1MAPK1HTTKMT2A | |
| SCHEMBL18706687 | 0.70 | SMN1; SMN2 (0.50) | MAPTTP53LMNASMN1; SMN2 | |
| SCHEMBL13719926 | 0.69 | CA2 (0.57) | SMN1; SMN2MAPK1ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |