Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 3/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.42 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21636392 | 0.75 | DYRK1A (0.55) | DYRK1ASLC6A4CLK1CDK5CDK5R1 | |
| SCHEMBL1137500 | 0.75 | DYRK1A (0.55) | DYRK1ASLC6A4CLK1CDK5CDK5R1 | |
| SCHEMBL31049262 | 0.75 | DYRK1A (0.55) | DYRK1ASLC6A4CLK1CDK5CDK5R1 | |
| SCHEMBL31188784 | 0.75 | DYRK1A (0.55) | DYRK1ASLC6A4CLK1CDK5CDK5R1 | |
| SCHEMBL19836840 | 0.75 | DYRK1A (0.55) | DYRK1ASLC6A4CLK1CDK5CDK5R1 | |
| SCHEMBL24743296 | 0.75 | DYRK1A (0.55) | DYRK1ASLC6A4CLK1CDK5CDK5R1 | |
| SCHEMBL29007190 | 0.73 | GPR84 (0.61) | DYRK1ASLC6A4CLK1CDK5CDK5R1 | |
| SCHEMBL20355101 | 0.72 | CSNK2A2 (0.33) | AR | |
| SCHEMBL20354843 | 0.71 | CSNK2A2 (0.49) | PARP1AR | |
| SCHEMBL25034434 | 0.71 | DYRK1A (0.50) | DYRK1ASLC6A4CLK1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645752-B2 | Sulfonyl substituted 1H-indoles as ligands for the 5-hydroxytryptamine receptors | WYETH LLC (US) | 2010-01-12 | — | — | US | disclosed |