Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 3/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.41 |
| ▸ | MPO | P05164 | 5/20 | 0.41 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31049406 | 0.80 | GPR84 (0.64) | GPR84SLC6A4MPO | |
| SCHEMBL19836840 | 0.75 | DYRK1A (0.55) | DYRK1ACLK1CDK5CDK5R1GSK3B | |
| SCHEMBL21636392 | 0.75 | DYRK1A (0.55) | DYRK1ACLK1CDK5CDK5R1GSK3B | |
| SCHEMBL31049280 | 0.75 | HTR2A (0.56) | GPR84AHRAR | |
| SCHEMBL24743296 | 0.75 | DYRK1A (0.55) | DYRK1ACLK1CDK5CDK5R1GSK3B | |
| SCHEMBL23658612 | 0.75 | GPR84 (0.58) | DYRK1AGPR84SLC6A4MPO | |
| SCHEMBL13544614 | 0.75 | DYRK1A (0.55) | DYRK1ACLK1CDK5CDK5R1GSK3B | |
| SCHEMBL1137500 | 0.75 | DYRK1A (0.55) | DYRK1ACLK1CDK5CDK5R1GSK3B | |
| SCHEMBL31188784 | 0.75 | DYRK1A (0.55) | DYRK1ACLK1CDK5CDK5R1GSK3B | |
| SCHEMBL28002632 | 0.75 | IMPDH2 (0.50) | GPR84CLK1CDK5CDK5R1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025080608-A1 | DESAMIDE ISOTRYPTAMINE TETRACYCLES FOR TREATING BRAIN DISORDERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-04-17 | — | — | WO | disclosed |
| WO-2025080609-A1 | ISOTRYPTAMINE TETRACYCLES FOR TREATING BRAIN DISORDERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-04-17 | — | — | WO | disclosed |
| CN-118359627-A | MTA synergistic PRMT5 inhibitor compounds having a tetracyclic fused ring structure | 烨辉医药科技(上海)有限公司 | 2024-07-19 | — | — | CN | disclosed |