Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13545864 | 0.89 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1NPC1TP53KMT2A | |
| SCHEMBL13545860 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1NPC1TP53KMT2A | |
| SCHEMBL13545881 | 0.85 | ALDH1A1 (0.61) | SMN1; SMN2ALDH1A1NPC1TP53AGTR1 | |
| SCHEMBL13545868 | 0.84 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1NPC1TP53KMT2A | |
| SCHEMBL13545799 | 0.84 | LMNA (0.54) | SMN1; SMN2ALDH1A1NPC1KMT2AMEN1 | |
| SCHEMBL13545870 | 0.81 | L3MBTL1 (0.49) | SMN1; SMN2ALDH1A1TP53KMT2AMAPK1 | |
| SCHEMBL13545858 | 0.78 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1NPC1TP53KMT2A | |
| SCHEMBL13545880 | 0.75 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1TP53LMNAHPGD | |
| SCHEMBL13545882 | 0.74 | ALDH1A1 (0.59) | SMN1; SMN2ALDH1A1TP53KMT2AMEN1 | |
| SCHEMBL13545811 | 0.73 | LMNA (0.57) | SMN1; SMN2ALDH1A1NPC1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022530-A1 | TETRAHYDROBENZOISOXAZOLE AND TETRAHYDROINDAZOLE DERIVATIVES AS MODULATORS OF THE MITOTIC MOTOR PROTEIN | MERCK PATENT GMBH (DE) | 2010-01-28 | — | — | US | disclosed |
| US-20100022530-A1 | TETRAHYDROBENZOISOXAZOLE AND TETRAHYDROINDAZOLE DERIVATIVES AS MODULATORS OF THE MITOTIC MOTOR PROTEIN | MERCK PATENT GMBH (DE) | 2010-01-28 | — | — | US | disclosed |
| WO-2008080455-A1 | TETRAHYDROBENZOISOXAZOLE - AND TETRAHYDROINDAZOLE DERIVATIVES AS MODULATORS OF THE MITOTIC MOTOR PROTEIN | MERCK PATENT GMBH (DE) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022530-A1 | TETRAHYDROBENZOISOXAZOLE AND TETRAHYDROINDAZOLE DERIVATIVES AS MODULATORS OF THE MITOTIC MOTOR PROTEIN | CCNB3, TUBB3, CCNB1 | SMN1; SMN2 153/4885ALDH1A1 2977/4885NPC1 4626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.