Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3612641 | 0.97 | HTT (0.36) | HTTALDH1A1RAB9AKDM4ECA1 | |
| SCHEMBL3617697 | 0.97 | HTT (0.36) | HTTALDH1A1RAB9AKDM4ECA1 | |
| SCHEMBL12811829 | 0.86 | EPHX1 (0.42) | ALDH1A1RAB9AKDM4ESMN1; SMN2EPHX1 | |
| SCHEMBL2676319 | 0.85 | EPHX1 (0.49) | HTTALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL13547213 | 0.85 | EPHX1 (0.49) | HTTALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL13547225 | 0.82 | KDM4E (0.46) | HTTALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL13547377 | 0.82 | KDM4E (0.43) | ALDH1A1KDM4EMAPT | |
| SCHEMBL13809020 | 0.80 | ALDH1A1 (0.34) | ALDH1A1RAB9ASMN1; SMN2EPHX1POLB | |
| SCHEMBL13547226 | 0.80 | RAB9A (0.34) | ALDH1A1RAB9AKDM4ESMN1; SMN2EPHX1 | |
| SCHEMBL3616970 | 0.79 | SMN1; SMN2 (0.51) | HTTALDH1A1RAB9ASMN1; SMN2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100009957-A1 | NOVEL INHIBITORS OF BETA-LACTAMASE | MERCK SHARP & DOHME CORP. | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009957-A1 | NOVEL INHIBITORS OF BETA-LACTAMASE | MGAM, SI, MGAM2 | HTT 4855/4885ALDH1A1 796/4885RAB9A 1833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.