Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 10/20 | 0.49 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13554345 | 0.87 | GSK3B (0.60) | YTHDC1GSK3BNPC1RAB9ALMNA | |
| SCHEMBL13267443 | 0.84 | KDM4E (0.61) | GSK3BNTRK1FLT3NPC1RAB9A | |
| SCHEMBL2056320 | 0.84 | HAO1 (0.57) | GSK3BPAK1NPC1RAB9ALMNA | |
| SCHEMBL13554360 | 0.82 | JAK2 (0.50) | GSK3BJAK2JAK1TYK2JAK3 | |
| SCHEMBL13554335 | 0.82 | GSK3B (0.55) | GSK3BNPC1RAB9ALMNA | |
| SCHEMBL15942803 | 0.81 | YTHDC1 (0.65) | YTHDC1GSK3BJAK2JAK1TYK2 | |
| SCHEMBL2468351 | 0.81 | YTHDC1 (0.65) | YTHDC1GSK3BJAK2JAK1TYK2 | |
| SCHEMBL13386937 | 0.79 | YTHDC1 (0.63) | YTHDC1GSK3BJAK2JAK1TYK2 | |
| SCHEMBL19001429 | 0.79 | YTHDC1 (0.63) | YTHDC1JAK2JAK1TYK2JAK3 | |
| SCHEMBL13386932 | 0.79 | YTHDC1 (0.58) | YTHDC1NTRK1PAK1FLT3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8802688-B2 | Substituted acetyl-coa carboxylase inhibitors | PFIZER INC. (US) | 2014-08-12 | — | — | US | disclosed |
| US-20120270893-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2012-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270893-A1 | SUBSTITUTED ACETYL-COA CARBOXYLASE INHIBITORS | ACACA, ACACB, ACAT1 | YTHDC1 4833/4885GSK3B 326/4885JAK2 1917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.