Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 8/20 | 0.43 |
| ▸ | PI4K2B | Q8TCG2 | 8/20 | 0.43 |
| ▸ | PI4K2A | Q9BTU6 | 8/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 8/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | PDE8A | O60658 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 2/20 | 0.36 |
| ▸ | AHCY | P23526 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13190439 | 0.88 | DGAT1 (0.40) | PI4KAPI4K2BPI4K2API4KBCFTR | |
| SCHEMBL13190316 | 0.88 | DGAT1 (0.49) | PI4KAPI4K2BPI4K2API4KBCFTR | |
| SCHEMBL13190315 | 0.84 | PI4KA (0.62) | PI4KAPI4K2BPI4K2API4KBEGFR | |
| SCHEMBL13190317 | 0.82 | CFTR (0.38) | PI4KAPI4K2BPI4K2API4KBCFTR | |
| SCHEMBL13189955 | 0.77 | DGAT1 (0.48) | PI4KAPI4K2BPI4K2API4KBCFTR | |
| SCHEMBL27870413 | 0.76 | XDH (0.58) | PI4KAPI4K2BPI4K2API4KBCFTR | |
| SCHEMBL27870411 | 0.76 | CFTR (0.49) | PI4KAPI4K2BPI4K2API4KBCFTR | |
| SCHEMBL27886646 | 0.76 | CFTR (0.49) | PI4KAPI4K2BPI4K2API4KBCFTR | |
| SCHEMBL27886637 | 0.76 | PI4KA (0.64) | PI4KAPI4K2BPI4K2API4KBCFTR | |
| SCHEMBL7438827 | 0.75 | PI4KA (0.52) | PI4KAPI4K2BPI4K2API4KBCFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10709718-B2 | Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof | METABASIS THERAPEUTICS, INC. (US) | 2020-07-14 | — | — | US | disclosed |
| US-10034891-B2 | Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof | METABASIS THERAPEUTICS, INC. (US) | 2018-07-31 | — | — | US | disclosed |
| US-20160263132-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE 1 (DGAT-1) AND USES THEREOF | CITIBANK, N.A., AS ADMINISTRATIVE AGENT | 2016-09-15 | — | — | US | disclosed |
| US-20160263132-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE 1 (DGAT-1) AND USES THEREOF | CITIBANK, N.A., AS ADMINISTRATIVE AGENT | 2016-09-15 | — | — | US | disclosed |
| US-9340566-B2 | Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof | METABASIS THERAPEUTICS, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-9340566-B2 | Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof | METABASIS THERAPEUTICS, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-20150166590-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE 1 (DGAT-1) AND USES THEREOF | CITIBANK, N.A., AS ADMINISTRATIVE AGENT | 2015-06-18 | — | — | US | disclosed |
| US-20150166590-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE 1 (DGAT-1) AND USES THEREOF | CITIBANK, N.A., AS ADMINISTRATIVE AGENT | 2015-06-18 | — | — | US | disclosed |
| US-8962618-B2 | Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof | METABASIS THERAPEUTICS, INC. (US) | 2015-02-24 | — | — | US | disclosed |
| US-8962618-B2 | Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof | METABASIS THERAPEUTICS, INC. (US) | 2015-02-24 | — | — | US | disclosed |
| EP-2408774-B1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE 1(DGAT-1) AND USES THEREOF | METABASIS THERAPEUTICS INC (US) | 2014-11-26 | — | — | EP | disclosed |
| US-20120270842-A1 | Inhibitors of Diacylglycerol O-Acyltransferase 1 (DGAT-1) and Uses Thereof | METABASIS THERAPEUTICS, INC. (US) | 2012-10-25 | — | — | US | disclosed |
| US-20120270842-A1 | Inhibitors of Diacylglycerol O-Acyltransferase 1 (DGAT-1) and Uses Thereof | METABASIS THERAPEUTICS, INC. (US) | 2012-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166590-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE 1 (DGAT-1) AND USES THEREOF | DGAT1, DGAT2, LCAT | PI4KA 653/4885PI4K2B 778/4885PI4K2A 826/4885 |
| US-10034891-B2 | Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof | DGAT1, DGAT2, PNLIP | PI4KA 514/4885PI4K2B 606/4885PI4K2A 642/4885 |
| US-10709718-B2 | Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof | DGAT1, DGAT2, LCAT | PI4KA 656/4885PI4K2B 827/4885PI4K2A 842/4885 |
| US-20160263132-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE 1 (DGAT-1) AND USES THEREOF | DGAT1, DGAT2, LCAT | PI4KA 653/4885PI4K2B 778/4885PI4K2A 826/4885 |
| US-20120270842-A1 | Inhibitors of Diacylglycerol O-Acyltransferase 1 (DGAT-1) and Uses Thereof | DGAT1, DGAT2, PNLIP | PI4KA 607/4885PI4K2B 757/4885PI4K2A 668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.