Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13560510 | 0.95 | SRD5A2 (0.35) | SRD5A2MAOAAKR1C3AKR1C2MCL1 | |
| SCHEMBL13560410 | 0.83 | SRD5A2 (0.34) | SRD5A2MAOAAKR1C3AKR1C2MCL1 | |
| SCHEMBL13560466 | 0.82 | SRD5A2 (0.55) | SRD5A2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL13560471 | 0.78 | CLK1 (0.37) | KDM4EL3MBTL1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3634756 | 0.77 | MAOA (0.45) | SRD5A2MAOAKDM4EMEN1KMT2A | |
| SCHEMBL13560586 | 0.77 | MAPK14 (0.35) | SRD5A2MAOA | |
| SCHEMBL13560567 | 0.77 | CCR2 (0.35) | KDM4EL3MBTL1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL13560475 | 0.75 | MAOA (0.37) | SRD5A2MAOAMCL1L3MBTL1 | |
| SCHEMBL3023791 | 0.74 | MAOA (0.43) | MAOAMCL1MEN1KMT2ATDP1 | |
| SCHEMBL13560478 | 0.73 | SRD5A2 (0.40) | SRD5A2MAOAMCL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |