Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 8/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17090375 | 1.00 | CRHR1 (0.44) | CRHR1GRIA4CARM1PRMT6GRIA2 | |
| SCHEMBL13565872 | 0.95 | CRHR1 (0.41) | CRHR1GRIA4CARM1PRMT6GRIA2 | |
| SCHEMBL13439168 | 0.92 | GRIA2 (0.44) | CRHR1GRIA4GRIA2NPY5RSIGMAR1 | |
| SCHEMBL11941022 | 0.92 | GRIA2 (0.44) | CRHR1GRIA4GRIA2NPY5RSIGMAR1 | |
| SCHEMBL13565446 | 0.92 | GRIA2 (0.44) | CRHR1GRIA4GRIA2NPY5RSIGMAR1 | |
| SCHEMBL11935090 | 0.89 | ACHE (0.41) | CRHR1GRIA4NPY5R | |
| SCHEMBL13564877 | 0.89 | CRHR1 (0.47) | CRHR1GRIA4GRIA2NPY5R | |
| SCHEMBL17090015 | 0.89 | CRHR1 (0.47) | CRHR1GRIA4GRIA2NPY5R | |
| SCHEMBL17090025 | 0.88 | GBA1 (0.46) | GBA1 | |
| SCHEMBL17090122 | 0.88 | ALDH1A1 (0.42) | CRHR1GRIA4CARM1PRMT6GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |