Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565136 | 0.95 | CRHR1 (0.44) | CRHR1GRIA4NPY5RCARM1PRMT6 | |
| SCHEMBL17090375 | 0.95 | CRHR1 (0.44) | CRHR1GRIA4NPY5RCARM1PRMT6 | |
| SCHEMBL13439168 | 0.90 | GRIA2 (0.44) | CRHR1CNR1CNR2GRIA4NPY5R | |
| SCHEMBL13565446 | 0.90 | GRIA2 (0.44) | CRHR1CNR1CNR2GRIA4NPY5R | |
| SCHEMBL11941022 | 0.90 | GRIA2 (0.44) | CRHR1CNR1CNR2GRIA4NPY5R | |
| SCHEMBL17090015 | 0.87 | CRHR1 (0.47) | CRHR1CNR1CNR2GRIA4NPY5R | |
| SCHEMBL11935090 | 0.87 | ACHE (0.41) | CRHR1CNR1CNR2GRIA4NPY5R | |
| SCHEMBL13564877 | 0.87 | CRHR1 (0.47) | CRHR1CNR1CNR2GRIA4NPY5R | |
| SCHEMBL17090122 | 0.86 | ALDH1A1 (0.42) | CRHR1GRIA4NPY5RALDH1A1CARM1 | |
| SCHEMBL13113858 | 0.86 | ALDH1A1 (0.42) | CRHR1GRIA4NPY5RALDH1A1CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |