Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 3/20 | 0.34 |
| ▸ | FABP4 | P15090 | 2/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565176 | 0.85 | HRH1 (0.41) | CNR2NPY1RNPY2RRORCPOLB | |
| SCHEMBL10115258 | 0.85 | ALDH1A1 (0.46) | RORCP2RX4POLBPDE4AMEN1 | |
| SCHEMBL11935716 | 0.82 | CARM1 (0.38) | NPY1RNPY2RRORCP2RX4POLB | |
| SCHEMBL11935682 | 0.82 | ACACB (0.38) | CNR2RORCMEN1ALDH1A1MAPT | |
| SCHEMBL13565527 | 0.81 | CTSL (0.38) | CNR2RORCEPHX2MEN1ALDH1A1 | |
| SCHEMBL13565836 | 0.81 | HDAC4 (0.41) | CNR2EPHX2 | |
| SCHEMBL13565477 | 0.80 | HDAC4 (0.41) | CNR2EPHX2ALDH1A1MAPT | |
| SCHEMBL13566088 | 0.79 | NPY1R (0.41) | NPY1RNPY2RRORCP2RX4POLB | |
| SCHEMBL13564791 | 0.75 | CNR2 (0.39) | CNR2POLBCYP19A1ALDH1A1MAPT | |
| SCHEMBL13565263 | 0.75 | CNR2 (0.48) | CNR2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |